Multiparametric magnetic resonance imaging and positron emission tomography findings in neurodegenerative diseases: Current status and future directions
| Autor: | Chandana Nagaraj, Manish Ora, Girish Bathla, Michael M. Graham, Yusuf Menda, Jitender Saini, Laura L Boles, Neetu Soni |
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| Rok vydání: | 2021 |
| Předmět: |
Movement disorders
Neuroimaging Disease 030218 nuclear medicine & medical imaging Primary progressive aphasia Parkinsonian syndromes 03 medical and health sciences 0302 clinical medicine Humans Medicine Dementia Radiology Nuclear Medicine and imaging Multiparametric Magnetic Resonance Imaging Review Articles medicine.diagnostic_test business.industry Neurodegenerative Diseases General Medicine medicine.disease Magnetic Resonance Imaging Positron emission tomography Positron-Emission Tomography Neurology (clinical) medicine.symptom business Neuroscience 030217 neurology & neurosurgery Frontotemporal dementia |
| Zdroj: | Neuroradiol J |
| ISSN: | 2385-1996 1971-4009 |
| Popis: | Neurodegenerative diseases (NDDs) are characterized by progressive neuronal loss, leading to dementia and movement disorders. NDDs broadly include Alzheimer’s disease, frontotemporal lobar degeneration, parkinsonian syndromes, and prion diseases. There is an ever-increasing prevalence of mild cognitive impairment and dementia, with an accompanying immense economic impact, prompting efforts aimed at early identification and effective interventions. Neuroimaging is an essential tool for the early diagnosis of NDDs in both clinical and research settings. Structural, functional, and metabolic imaging modalities, including magnetic resonance imaging (MRI) and positron emission tomography (PET), are widely available. They show encouraging results for diagnosis, monitoring, and treatment response evaluation. The current review focuses on the complementary role of various imaging modalities in relation to NDDs, the qualitative and quantitative utility of newer MRI techniques, novel radiopharmaceuticals, and integrated PET/MRI in the setting of NDDs. |
| Databáze: | OpenAIRE |
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