Could Autoimmune Disease Contribute to the Abscopal Effect in Metastatic Hepatocellular Carcinoma?
| Autor: | Steven Pans, Carolien Beyls, Karin Haustermans, Christophe Deroose, Dirk Vanbeckevoort, Chris Verslype, Jeroen Dekervel |
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| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
medicine.medical_specialty Carcinoma Hepatocellular Cirrhosis Biopsy Remission Spontaneous Bone Neoplasms Chronic liver disease Gastroenterology 03 medical and health sciences Liver disease 0302 clinical medicine Liver Function Tests Positron Emission Tomography Computed Tomography Internal medicine Humans Medicine Radiotherapy Hepatology business.industry Liver Neoplasms Hepatitis C Middle Aged Hepatitis B medicine.disease Magnetic Resonance Imaging Hepatitis Autoimmune Treatment Outcome 030104 developmental biology Liver Cervical Vertebrae Female 030211 gastroenterology & hepatology Steatohepatitis Tomography X-Ray Computed business Varices Transient elastography |
| Zdroj: | Hepatology. 72:1152-1154 |
| ISSN: | 1527-3350 0270-9139 |
| Popis: | Background: Variceal haemorrhage resulting from portal hypertension is a feared complication of cirrhosis Historically, endoscopic screening of individuals with cirrhosis has been performed to identify those at highest risk of variceal haemorrhage who would benefit from interventions Noninvasive prediction of oesophageal varices may identify patients considered to be at low risk of varices, for whom unnecessary endoscopic screening could be avoided, thus reducing risks to patients and costs to health services This is relevant during the SARS-COV-2 pandemic and for remote located patients Aims: To examine the role of noninvasive liver fibrosis and chronic liver disease assessments for prediction of oesophageal varices Methods: Data on adult patients with cirrhosis from various liver disorders over 8 years at a tertiary hospital were assessed Patient age, sex, liver disease aetiology, full blood count, serum liver biochemistry, renal function tests, liver ultrasound (US), transient elastography liver stiffness measurement (LSM) and endoscopy results were retrospectively recorded Noninvasive liver fibrosis and chronic liver disease severity using Fibrosis-4 index (FIB-4), the Model for End-stage Liver Disease (MELD) score and Baveno VI criteria were computed and the LSM was documented The noninvasive assessment results were correlated with US and endoscopy reports of cirrhosis, portal hypertension or oesophageal varices Results: We identified 303 patients, 69% male Mean (standard deviation) age 60 (11) years Liver disease aetiologies were predominantly alcohol (23%), hepatitis C (HCV) (37%), non-alcoholic steatohepatitis (NASH) (13%) or hepatitis B (HBV)(5%) Patients with varices had higher LSM, FIB-4, MELD score, INR, but lower serum albumin and platelet count compared with those without varices (p |
| Databáze: | OpenAIRE |
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