In Vivo Endothelial Cell Density Decline in the Early Postoperative Phase After Descemet Membrane Endothelial Keratoplasty
| Autor: | Lamis Baydoun, Isabel Dapena, Alina Miron, Sontje-Chiao Schaal, Silke Oellerich, Lisanne Ham, Gerrit R. J. Melles, Marieke Bruinsma |
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| Rok vydání: | 2018 |
| Předmět: |
Adult
Male medicine.medical_specialty genetic structures Descemet membrane Fuchs Endothelial Dystrophy Population 03 medical and health sciences 0302 clinical medicine Postoperative Complications Descemet membrane endothelial keratoplasty In vivo Ophthalmology Medicine Humans education Descemet Membrane cell density decrease Aged Aged 80 and over education.field_of_study business.industry endothelial cell density Fuchs' Endothelial Dystrophy Fuchs endothelial corneal dystrophy Eye bank Corneal Endothelial Cell Loss Middle Aged Endothelial stem cell Endothelial cell density corneal transplantation Descemet Stripping Endothelial Keratoplasty 030221 ophthalmology & optometry Female business 030217 neurology & neurosurgery |
| Zdroj: | Cornea, 37(6), 673-677 |
| ISSN: | 1536-4798 |
| Popis: | PURPOSE To evaluate endothelial cell density (ECD) in the first 6 months after Descemet membrane endothelial keratoplasty (DMEK) by eliminating method error as a confounding variable. METHODS From 24 DMEK eyes operated for Fuchs endothelial corneal dystrophy, from which specular microscopy images could be taken at 1 day and 6 months postoperatively, ECD values were compared between these 2 time points. RESULTS Using the 1-day ECD measurement as baseline, mean ECD decreased from 1913 (±326) cells/mm to 1524 (±393) cells/mm at 6 months, a decline of -18 (±19)%. With the 1-week ECD as baseline [1658 (±395) cells/mm], the decline at 6 months was -6 (±19)% and when using preoperative ECD as baseline [2521 (±122) cells/mm], the decline was -39 (±16)% at 6 months. CONCLUSIONS After DMEK, ECD shows an in vivo decline of 18% from 1 day to 6 months postoperatively, with a sharp 13% drop in the first week, and a slower decrease thereafter. The remaining difference of 20% from preoperative ECD values may be attributed to a measurement error in the eye bank with an overestimation of the graft's viable endothelial cell population and/or intraoperative trauma to the graft. |
| Databáze: | OpenAIRE |
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