Single center experience on the production of fluorine-18 radiopharmaceuticals using a 7.5 MeV cyclotron: capabilities and challenges
| Autor: | Mohammad Reza Pourkhessalian, Alexis Vrachimis, Andreas Fesas |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
Technology
Materials science 020209 energy General Chemical Engineering Science Cyclotron General Physics and Astronomy chemistry.chemical_element 02 engineering and technology Radiotracer production 030218 nuclear medicine & medical imaging law.invention Dose on demand 03 medical and health sciences 0302 clinical medicine Low energy law 0202 electrical engineering electronic engineering information engineering General Materials Science General Environmental Science Fluorine-18 radiopharmaceuticals Radiochemistry General Engineering Low energy cyclotron equipment and supplies Single patient chemistry Fluorine General Earth and Planetary Sciences FMISO |
| Zdroj: | SN Applied Sciences, Vol 2, Iss 5, Pp 1-6 (2020) |
| ISSN: | 2523-3971 2523-3963 |
| Popis: | A plethora of cyclotron options have been developed to fulfil the demands of nuclear medicine industries in PET and SPECT radioisotopes. As a remote site, the difficulties of transporting fluorine 18 radiopharmaceuticals for PET examinations were overcome by the installation of a 7.5 MeV cyclotron for in-house production. The addition of a third-party synthesis module enabled the synthesis of 7 additional radiotracers according to a ‘’dose on demand’’ principle. Radiochemical yield is considered the primary factor in producing sufficient activity for a single patient dose, since low energy cyclotrons can only offer low initial activities. We hereby report the average radiochemical yields, synthesis times and doses per production for [18F]FDG, [18F]PSMA-1007, [18F]DOPA, [18F]FET, [18F]FLT, [18F]FMISO, [18F]Choline and [18F]FES using a BG75 cyclotron and a Neptis Mosaic-RS. Additionally, the presence of radionuclidic impurities in the final product was examined. |
| Databáze: | OpenAIRE |
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