Relationship between Decrease in Serum Sodium Level and Bone Mineral Density in Osteoporotic Fracture Patients
| Autor: | Jae-Hyuk Lee, Hye Jeong Kim, Mi Kyung Kwak, Dughyun Choi, Kyo Il Suh, Myung Hi Yoo, Dong Won Byun, Hyeong Kyu Park |
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| Rok vydání: | 2015 |
| Předmět: |
Bone mineral
medicine.medical_specialty business.industry Endocrinology Diabetes and Metabolism Serum sodium level Osteoporosis Osteoporotic fractures Odds ratio medicine.disease Gastroenterology Confidence interval Endocrinology Internal medicine Medicine Original Article Osteoporotic fracture Risk factor business Hyponatremia |
| Zdroj: | Journal of Bone Metabolism |
| ISSN: | 2287-7029 2287-6375 |
| DOI: | 10.11005/jbm.2015.22.1.9 |
| Popis: | Background Recently, it has been suggested that decrease in serum sodium level is associated with osteoporosis. However, no study in Korea has reported the association of decrease in serum sodium level with osteoporosis. In this study, we investigated the relationship between the decrease in serum sodium level and severity of osteoporotic fracture in patients. Methods We enrolled 290 subjects who were admitted and operated at Soonchunhyang University Hospital due to major fractures. For the control group, we enrolled 1,027 subjects who visited a health promotion center. We carried a 1:1 matching with age and sex from the case group. Results In a total of 164 age- and sex-matched subjects, serum sodium level was significantly lower in the fracture group than in the non-fracture group (P=0.001). Serum sodium level was significantly lower in the severe osteoporosis group than that in the non-severe osteoporosis group (P=0.002). Old age and decrease in serum sodium level were independent risk factors of osteoporosis (odds ratio [OR]=1.088, P=0.008, confidence interval [CI]=[1.022-1.157]; OR= 0.840, P=0.037, CI=0.713-0.989). Conclusions Serum sodium level was significantly lower in the fracture group than that in the non-fracture group and in the severe osteoporosis group than that in the non-severe osteoporosis group. Based on our results, the decrease in serum sodium level could be an independent risk factor for osteoporosis. |
| Databáze: | OpenAIRE |
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