A Complex Adenovirus-Vectored Vaccine against Rift Valley Fever Virus Protects Mice against Lethal Infection in the Presence of Preexisting Vector Immunity
| Autor: | Jan Woraratanadharm, Adam Penn-Nicholson, Danher Wang, David H. Holman, John Y. Dong, Ellen M. Maher, Min Luo, Michael R. Holbrook, Mary-Katherine Harr |
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| Rok vydání: | 2009 |
| Předmět: |
Male
Microbiology (medical) Rift Valley Fever Genetic Vectors Clinical Biochemistry Immunology Biology Antibodies Viral medicine.disease_cause Virus Adenoviridae Viral vector Microbiology Mice Immune system Immunity medicine Animals Immunology and Allergy Rift Valley fever Viral Structural Proteins Viral Vaccine Viral Vaccines Vaccine Research Rift Valley fever virus medicine.disease Survival Analysis Virology Vaccination |
| Zdroj: | Clinical and Vaccine Immunology. 16:1624-1632 |
| ISSN: | 1556-679X 1556-6811 |
| DOI: | 10.1128/cvi.00182-09 |
| Popis: | Rift Valley fever virus (RVFV) has been cited as a potential biological-weapon threat due to the serious and fatal disease it causes in humans and animals and the fact that this mosquito-borne virus can be lethal in an aerosolized form. Current human and veterinary vaccines against RVFV, however, are outdated, inefficient, and unsafe. We have incorporated the RVFV glycoprotein genes into a nonreplicating complex adenovirus (CAdVax) vector platform to develop a novel RVFV vaccine. Mice vaccinated with the CAdVax-based vaccine produced potent humoral immune responses and were protected against lethal RVFV infection. Additionally, protection was elicited in mice despite preexisting immunity to the adenovirus vector. |
| Databáze: | OpenAIRE |
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