Detecting of p16 Autoantibody as a Potential Early Diagnostic Serum Biomarker in Patients with Cervical Cancer
| Autor: | Shuang Xu, Baosheng Sun, Kuo Jiang, Shilong Sun, Siyao Li, Linlin Liu, Kuang-Hui Lee, Mingmei Huangfu |
|---|---|
| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
Oncology Adult medicine.medical_specialty Pathology Uterine Cervical Neoplasms Enzyme-Linked Immunosorbent Assay General Biochemistry Genetics and Molecular Biology Benign tumor 03 medical and health sciences 0302 clinical medicine Antigen Predictive Value of Tests Internal medicine medicine Biomarkers Tumor Humans In patient Cyclin-Dependent Kinase Inhibitor p16 Early Detection of Cancer Autoantibodies Neoplasm Staging Cervical cancer biology business.industry Autoantibody Case-control study Middle Aged medicine.disease Neoplasm Proteins Up-Regulation 030104 developmental biology 030220 oncology & carcinogenesis Predictive value of tests Case-Control Studies biology.protein Female Antibody business |
| Zdroj: | Clinical laboratory. 62(6) |
| ISSN: | 1433-6510 |
| Popis: | Over-expression of tumor-associated antigens (TAAs) may trigger secretion of their auto-antibodies. The present work was designed to test whether circulating antibody to P16 protein-derived antigens was altered in cervical cancer.141 cases of cervical cancer patients, 133 cases of cervical benign tumor patients, and 153 healthy volunteers matched in age were recruited. The level of circulating P16 auto-antibody was tested using an ELISA developed in-house with linear peptide antigens derived from the P16 protein.The P16 auto-antibody in the malignant tumor group had a significantly higher level than the healthy control group and the benign tumor group (t = 4.016, p0.001; t = 3.879, p0.001). Patients with stage I cervical cancer have the highest level of P16 autoantibody and the sensitivity against90% specificity was 20.3%.The circulating auto-antibody to P16 may be one of a series of potential biomarkers with early prognostic values for cervical cancer. |
| Databáze: | OpenAIRE |
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