MicroRNA-503 serves an oncogenic role in laryngeal squamous cell carcinoma via targeting programmed cell death protein 4
| Autor: | Xuan Zhou, Yu Shuang, Yongwang Huang, Lun Zhang, Chao Li |
|---|---|
| Rok vydání: | 2017 |
| Předmět: |
Male
0301 basic medicine Cancer Research Down-Regulation Biology Biochemistry Metastasis 03 medical and health sciences 0302 clinical medicine Cell Line Tumor microRNA Genetics medicine Carcinoma Humans Neoplasm Invasiveness Programmed Cell Death Protein 4 3' Untranslated Regions Laryngeal Neoplasms Molecular Biology Cell Proliferation therapy Base Sequence Oncogene RNA-Binding Proteins Cancer Articles Middle Aged Cell cycle medicine.disease programmed cell death protein 4 Up-Regulation Gene Expression Regulation Neoplastic MicroRNAs laryngeal squamous cell carcinoma HEK293 Cells 030104 developmental biology Oncology 030220 oncology & carcinogenesis Carcinoma Squamous Cell Cancer research Molecular Medicine Female prognosis Apoptosis Regulatory Proteins microRNA-503 A431 cells |
| Zdroj: | Molecular Medicine Reports |
| ISSN: | 1791-3004 1791-2997 |
| DOI: | 10.3892/mmr.2017.7278 |
| Popis: | Laryngeal squamous cell carcinoma (LSCC), the most common form of laryngeal carcinoma, is an aggressive malignancy that demonstrates the second highest rate of morbidity of all head and neck squamous cell carcinomas. The abnormal expression of microRNAs (miRs) has been demonstrated in a number of types of human cancer, and they have been demonstrated to be oncogenes or tumour suppressor genes. miR‑503 has been studied in various types of human cancer; however, the expression level, roles and underlying mechanisms in LSCC remain unknown. In the present study, it was demonstrated that miR‑503 was significantly upregulated in LSCC tissues and cell lines. The level of miR‑503 in LSCC tissues was correlated with thyroid cartilage invasion, lymph node metastasis, and tumour, node and metastasis stage. In addition, down‑regulation of miR‑503 inhibited cell proliferation and invasion in LSCC. Programmed cell death protein 4 (PDCD4) was identified to be a direct target gene of miR‑503. PDCD4 overexpression could mimic the roles of miR‑503 underexpression in LSCC. Furthermore, PDCD4 was down‑regulated in LSCC tissues and this correlated with the miR‑503 expression level. In conclusion, these results suggested that miR‑503 promotes tumour growth and invasion by directly targeting PDCD4. The identification of the miR‑503/PDCD4 axis may provide novel targets for LSCC treatment and improve prognosis. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|