Metastatic HER2+ Breast Cancer: A Potentially Curable Disease?
| Autor: | Giuseppe Gullo, Lisa Mary Prior, Hannah Featherstone, Marvin Lim, Clare D'Arcy, Hazel Murray, John Crown, Cian Ward |
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| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
CA15-3 Oncology medicine.medical_specialty her2 Estrogen receptor Disease 03 medical and health sciences breast cancer 0302 clinical medicine Breast cancer Trastuzumab Internal medicine medicine skin and connective tissue diseases Human Epidermal Growth Factor Receptor 2 business.industry General Engineering Complete remission Retrospective cohort study medicine.disease metastatic trastuzumab 030104 developmental biology 030220 oncology & carcinogenesis durable complete remission business medicine.drug |
| Zdroj: | Cureus |
| ISSN: | 2168-8184 |
| Popis: | The advent of trastuzumab and other human epidermal growth factor receptor 2 (HER2)-directed therapies has revolutionized the treatment of metastatic HER2-positive breast cancer, leading to prolonged survival and appreciable clinical benefit for a substantial subset of patients. Previously, in a retrospective study at our institution, we observed that nearly 10% of patients achieved a durable complete remission (DCR) following a combination of HER2-directed therapy and cytotoxic chemotherapy. We are currently expanding this study to include patients who were treated since the initial introduction of trastuzumab. From our ongoing study, we present a selected case series of three patients with metastatic HER2-positive breast cancer who achieved a DCR. It is theorized that metastatic HER2-positive breast cancer may be potentially curable in certain patients with favorable clinicopathological and molecular factors, which the patients within our case series mostly demonstrate. These include de novo presentation, estrogen receptor (ER)-negative status, limited disease burden, and absence of deleterious gene or pathway mutations. More research is needed in order to incorporate these findings into clinical practice. |
| Databáze: | OpenAIRE |
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