The Effect of Korean Red Ginseng on Symptoms and Inflammation in Patients With Allergic Rhinitis
| Autor: | Seon Tae Kim, Jin Uk Jeong, Kwang Pil Ko, Tae Kyu Kang, Joo Hyun Jung, Jae Hwan Oh |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
Adult
Male 0301 basic medicine medicine.medical_specialty medicine.medical_treatment Histamine Antagonists Panax Inflammation Immunoglobulin E Placebo Gastroenterology Leukocyte Count 03 medical and health sciences Ginseng 0302 clinical medicine Internal medicine medicine Humans rhinorrhea biology Plant Extracts business.industry Nausea Middle Aged Eosinophil Rhinitis Allergic Abdominal Pain Eosinophils 030104 developmental biology medicine.anatomical_structure Otorhinolaryngology 030220 oncology & carcinogenesis Peak Nasal Inspiratory Flow biology.protein Cytokines Female Antihistamine medicine.symptom Pulmonary Ventilation business |
| Zdroj: | Ear, Nose & Throat Journal. 100:712S-719S |
| ISSN: | 1942-7522 0145-5613 |
| Popis: | Korean red ginseng (KRG) has been traditionally used in Korea for health improvement. However, the clinical effect of KRG intake on the symptoms in patients with allergic rhinitis remains unknown. Our study was performed to identify the clinical effects of KRG on patients with allergic rhinitis and to examine the effect of KRG on allergic inflammatory reaction. We evaluated 60 patients with allergic rhinitis. All the patients were treated for 4 weeks. The patients were divided into 3 groups, according to the medication. Twenty patients were treated with KRG, 20 patients with the placebo, and 20 patients with the antihistamine. The patients recorded their symptoms in a daily symptom diary card. The patients checked the peak nasal inspiratory flow rate 2 times a day. Total serum immunoglobulin E (IgE) and serum-specific IgE were measured by ImmunoCap method before and after 4-week medication. The Th2 cytokines interleukin-4 (IL-4), IL-5, and IL-10 were checked in the serum before and after the 4-week treatment. The eosinophil counts in the nasal smears were checked. Korean red ginseng group has shown the significant improvement in rhinorrhea, nasal itching, and eye itching. Both the antihistamine and KRG groups showed a significant decrease in total IgE level at the end of treatment. The serum IL-4 level and eosinophil counts in the nasal smears were significantly decreased both in the antihistamine and in the KRG groups. In conclusion, KRG might be a useful treatment modality for patients with allergic rhinitis. |
| Databáze: | OpenAIRE |
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