In Vitro Modulation of Glibenclamide Transport by P-glycoprotein Inhibitory Antidiabetic African Plant Extracts
| Autor: | Jose M. Prieto, Elisabetta Chieli, Udoamaka F. Ezuruike |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
Herb-Drug Interactions
Pharmaceutical Science Syzygium guineense ATP-binding cassette transporter Pharmacology 01 natural sciences Analytical Chemistry Glibenclamide chemistry.chemical_compound Drug Discovery Glyburide medicine Humans Hypoglycemic Agents ATP Binding Cassette Transporter Subfamily B Member 1 Medicine African Traditional P-glycoprotein Plants Medicinal biology 010405 organic chemistry Plant Extracts Organic Chemistry Ximenia americana Glutathione Hep G2 Cells biology.organism_classification In vitro 0104 chemical sciences 010404 medicinal & biomolecular chemistry Complementary and alternative medicine chemistry biology.protein Molecular Medicine Efflux Caco-2 Cells medicine.drug |
| Zdroj: | Planta medica. 85(11-12) |
| ISSN: | 1439-0221 |
| Popis: | The rise of diabetes incidence in Nigeria enhances the use of popular remedies that may interact with conventional therapies. The aqueous extracts of 27 popular Nigerian “antidiabetic” plants were tested for their in vitro effects on glutathione levels within HepG2 cells, P-glycoprotein (P-gp)-mediated Rh-123 efflux activity in Caco-2 vincristine-resistant cells, and modulation of glibenclamide transport in Caco-2 monolayers. The extract from Ximenia americana significantly depleted intracellular glutathione at 100 µg/mL similarly to the reference buthionine sulphoximine (p |
| Databáze: | OpenAIRE |
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