Second-Generation Histamine H2-Receptor Antagonists with Gastric Mucosal Defensive Properties

Autor:	Kazuhiko Ishihara, Takafumi Ichikawa, Kyoko Hotta
Rok vydání:	2009
Předmět:	Pharmacology General Medicine Biology Gastric Acid Structure-Activity Relationship chemistry.chemical_compound Histamine H2 Antagonists chemistry Histamine H2 receptor Gastric Mucosa Drug Discovery Animals Humans Receptors Histamine H2 Histamine
Zdroj:	Mini-Reviews in Medicinal Chemistry. 9:581-589
ISSN:	1389-5575
Popis:	Unlike the earlier agents in this class, certain of the newer histamine H(2)-receptor antagonists (so-called second-generation HB(2B)-receptor antagonists) have recently been reported to promote gastric mucosal defenses. We review herein the structure, specificity, and mechanisms of these agents with a special focus on their cytoprotective/gastroprotective actions.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c5c3d86d4e8387426ce9b64f1c1b0829 https://doi.org/10.2174/138955709788167646 Zobrazit plný text záznamu