| Autor: |
Stamatios Kokkinakis, Evangelos I Kritsotakis, Neofytos Maliotis, Ioannis Karageorgiou, Emmanuel Chrysos, Konstantinos Lasithiotakis |
| Rok vydání: |
2022 |
| Předmět: |
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| Zdroj: |
Hepatobiliary & Pancreatic Diseases International. 21:527-537 |
| ISSN: |
1499-3872 |
| Popis: |
In the past decades, the perioperative management of patients undergoing pancreaticoduodenectomy (PD) has undergone major changes worldwide. This review aimed to systematically determine the burden of complications of PD performed in the last 10 years.A systematic review was conducted in PubMed for randomized controlled trials and observational studies reporting postoperative complications in at least 100 PDs from January 2010 to April 2020. Risk of bias was assessed using the Cochrane RoB2 tool for randomized studies and the methodological index for non-randomized studies (MINORS). Pooled complication rates were estimated using random-effects meta-analysis. Heterogeneity was investigated by subgroup analysis and meta-regression.A total of 20 randomized and 49 observational studies reporting 63 229 PDs were reviewed. Mean MINORS score showed a high risk of bias in non-randomized studies, while one quarter of the randomized studies were assessed to have high risk of bias. Pooled incidences of 30-day mortality, overall complications and serious complications were 1.7% (95% CI: 0.9%-2.9%; IPooled complication rates estimated in this study may be used to counsel patients scheduled to undergo a PD and to set benchmarks against which centers can audit their practice. However, cautious interpretation is necessary due to substantial heterogeneity. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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