Robust associations of four new chromosome regions from genome-wide analyses of type 1 diabetes
| Autor: | Jason P. Hafler, Sarah F. Field, David Clayton, Neil Walker, Ellen C. Adlem, Meeta Maisuria, Adrian Vella, Stephen C. L. Gough, Jennie H M Yang, Helen Schuilenburg, David B. Dunger, Jeffrey S. Szeszko, Sergey Nejentsev, Nigel R. Ovington, Linda S. Wicker, William Meadows, Deborah J. Smyth, Gillian Coleman, Barry C. Healy, Sarah Nutland, Matthew J. Simmonds, Kate Downes, John A. Todd, Alex C. Lam, Lauren R. Zeitels, H. T. Leung, Oliver S. Burren, Chris Wallace, Felicity Payne, Constantin Ionescu-Tirgoviste, Jason D. Cooper, Luc J. Smink, Helen Stevens, Rebecca Bailey, Joanna M. M. Howson, James E. Allen, Vincent Plagnol, Cristian Guja, Joanne M. Heward, Christopher E. Lowe |
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| Jazyk: | angličtina |
| Rok vydání: | 2007 |
| Předmět: |
Autoimmune disease
Genetics Type 1 diabetes Adolescent Genome Human Case-control study Chromosome Mapping Single-nucleotide polymorphism Locus (genetics) CLEC16A Disease Biology medicine.disease Polymorphism Single Nucleotide Article Diabetes Mellitus Type 1 Chromosome regions Case-Control Studies medicine Humans Genetic Predisposition to Disease |
| Zdroj: | Nature genetics. 39(7) |
| ISSN: | 1546-1718 1061-4036 |
| Popis: | The Wellcome Trust Case Control Consortium (WTCCC) primary genome-wide association (GWA) scan1 on seven diseases, including the multifactorial, autoimmune disease, type 1 diabetes (T1D), shows significant association (P < 5 × 10−7 between T1D and six chromosome regions: 12q24, 12q13, 16p13, 18p11, 12p13 and 4q27. Here, we attempted to validate these and six other top findings in 4,000 individuals with T1D, 5,000 controls and 2,997 family trios that were independent of the WTCCC study. We confirmed unequivocally the associations of 12q24, 12q13, 16p13 and 18p11 (Pfollow-up ≤ 1.35 × 10−9; Poverall ≤ 1.15 × 10−14), leaving eight regions with small effects or false-positive associations with T1D. We also obtained evidence for chromosome 18q22 (Poverall = 1.38 × 10−8) from a genome-wide association study of nonsynonymous SNPs. Several regions, including 18q22 and 18p11, showed association with autoimmune thyroid disease. This study increases the number of T1D loci with compelling evidence from six to at least ten. |
| Databáze: | OpenAIRE |
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