Pretransplantation fetal-maternal microchimerism in pediatric liver transplantation from mother
| Autor: | Sung Woo Ahn, Min Su Park, YoungRok Choi, Suk Kyun Hong, Hye Young Ahn, Myoung Hee Park, Hae Won Lee, Jeik Byun, Nam-Joon Yi, Eun Young Song, Kyung-Suk Suh, Kwang-Woong Lee, Hyo Sin Kim, Kyungchul Yoon, Hyeyoung Kim |
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| Rok vydání: | 2017 |
| Předmět: |
Graft Rejection
Male medicine.medical_specialty Adolescent Biopsy medicine.medical_treatment Mothers Human leukocyte antigen 030230 surgery Liver transplantation Chimerism Gastroenterology 03 medical and health sciences 0302 clinical medicine Antigen Pregnancy Internal medicine medicine Retrospective Cohort Study Humans In patient 030212 general & internal medicine Child Maternal-Fetal Exchange Non-inherited maternal antigen Fetus business.industry Infant Newborn Maternal graft Infant Graft survival Microchimerism HLA-DR Antigens General Medicine Allografts Tissue Donors Peripheral blood Maternal microchimerism Liver Child Preschool Preoperative Period Female business Biopsy-proven cellular rejection Liver Failure |
| Zdroj: | World Journal of Gastroenterology |
| ISSN: | 1007-9327 |
| DOI: | 10.3748/wjg.v23.i45.8017 |
| Popis: | Aim To investigate the rates of pretransplantation fetal-maternal microchimerism (MC) and its effect on rejection in children receiving maternal liver grafts. Methods DNA or blood samples before liver transplantation (LT) were available in 45 pediatric patients and their mothers. The presence of pretransplantation MC to non-inherited maternal antigens (NIMAs) (NIMA-MC) in the peripheral blood was tested using nested PCR-single-strand conformation polymorphism analysis for the human leukocyte antigen (HLA)-DRB1 alleles. NIMA-MC was successfully evaluated in 26 of the 45 children. Among these 45 pediatric LT recipients, 23 children (51.1%) received transplants from maternal donors and the other 22 from non-maternal donors. Results Among these 26 children, pretransplantation NIMA-MC was detected in 23.1% (n = 6), 6.1 (range, 0.8-14) years after birth. Among the children with a maternal donor, the rate of biopsy-proven cellular rejection (BPCR) was 0% in patients with NIMA-MC positivity (0/3) and those with HLA-DR identity with the mother (0/4), but it was 50% in those with NIMA-MC negativity (5/10). Patients with NIMA-MC positivity or HLA-DR identity with the mother showed significantly lower BPCR rate compared with NIMA-MC-negative patients (0% vs 50%, P = 0.04). NIMA-MC-positive patients tended to show lower BPCR rate compared with NIMA-MC-negative patients (P = 0.23). Conclusion The presence of pretransplantation NIMA-MC or HLA-DR identity with the mother could be associated with BPCR-free survival in pediatric recipients of LT from maternal donors. |
| Databáze: | OpenAIRE |
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