Gamma-Terpinene Modulates Acute Inflammatory Response in Mice
| Autor: | Ana Luisa de Araujo Lima, Marcia Regina Piuvezam, Claudio Roberto Bezerra-Santos, Theresa Ramalho, Maria Talita Pacheco de Oliveira |
|---|---|
| Rok vydání: | 2015 |
| Předmět: |
Lipopolysaccharides
Male medicine.medical_treatment Administration Oral Pharmaceutical Science Inflammation Vascular permeability Cyclohexane Monoterpenes Peritonitis Pharmacology Lung injury Carrageenan Dinoprostone Analytical Chemistry Mice chemistry.chemical_compound Edema Drug Discovery medicine Animals Mice Inbred BALB C Dose-Response Relationship Drug business.industry Anti-Inflammatory Agents Non-Steroidal Organic Chemistry Extravasation Disease Models Animal Cytokine Complementary and alternative medicine chemistry Immunology Monoterpenes Cytokines Molecular Medicine Female Tumor necrosis factor alpha medicine.symptom business Histamine |
| Zdroj: | Planta Medica. 81:1248-1254 |
| ISSN: | 1439-0221 0032-0943 |
| DOI: | 10.1055/s-0035-1546169 |
| Popis: | The monoterpene gamma-terpinene is a natural compound present in essential oils of a wide variety of plants, including the Eucalyptus genus, which has been reported to possess anti-inflammatory activity. The goal of this study was to evaluate the effect of gamma-terpinene on several in vivo experimental models of acute inflammation. Swiss mice were pretreated with gamma-terpinene and subjected to protocols of paw edema with different phlogistic agents such as carrageenan, prostaglandin-E2, histamine, or bradykinin. The microvascular permeability was measured by intraperitoneal injection of acetic acid and measuring the amount of protein extravasation. Carrageenan-induced peritonitis was used to analyze the effect of gamma-terpinene on inflammatory cell migration and cytokine production. We also developed an acute lung injury protocol to define the anti-inflammatory effect of gamma-terpinene. Mice pretreated with gamma-terpinene displayed reduced paw edema induced by carrageenan from 1-24 h after challenge. A similar reduction was observed when gamma-terpinene was administered after stimulation with PGE2, bradykinin, and histamine. Treatment with gamma-terpinene also inhibited fluid extravasation in the acetic acid model of microvascular permeability. In a carrageenan-induced peritonitis model, gamma-terpinene treatment reduced neutrophil migration as well as the production of interleukin-1β and tumor necrosis factor-α when compared to nontreated animals, and in the acute lung injury protocol, gamma-terpinene diminished the neutrophil migration into lung tissue independently of the total protein extravasation in the lung. These data demonstrate that, in different models of inflammation, treatment with gamma-terpinene alleviated inflammatory parameters such as edema and pro-inflammatory cytokine production, as well as cell migration into the inflamed site, and that this monoterpene has anti-inflammatory properties. |
| Databáze: | OpenAIRE |
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