Distributed cell assemblies spanning prefrontal cortex and striatum
| Autor: | Sidney I. Wiener, Michaël B. Zugaro, Virginie J. Oberto, HongYing Gao, Ralitsa Todorova, Céline J. Boucly |
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| Přispěvatelé: | Center for Interdisciplinary Research in Biology, College de France, CNRS, INSERM, PSL Research University, 75231 Paris, France. (CIRB), Centre interdisciplinaire de recherche en biologie (CIRB), Labex MemoLife, École normale supérieure - Paris (ENS-PSL), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Collège de France (CdF (institution))-Ecole Superieure de Physique et de Chimie Industrielles de la Ville de Paris (ESPCI Paris), Université Paris sciences et lettres (PSL)-École normale supérieure - Paris (ENS-PSL), Université Paris sciences et lettres (PSL)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Wiener, Sidney I |
| Rok vydání: | 2021 |
| Předmět: |
[SDV]Life Sciences [q-bio]
Prefrontal Cortex Striatum Biology General Biochemistry Genetics and Molecular Biology 03 medical and health sciences 0302 clinical medicine Rhythm Reward Animals Theta Rhythm Prefrontal cortex Association (psychology) Associative property 030304 developmental biology Neurons 0303 health sciences Mechanism (biology) Cognitive flexibility Cognition Corpus Striatum Rats [SDV] Life Sciences [q-bio] General Agricultural and Biological Sciences Neuroscience 030217 neurology & neurosurgery |
| Zdroj: | Current Biology-CB Current Biology-CB, 2021, ⟨10.1016/j.cub.2021.10.007⟩ Current Biology-CB, Elsevier, 2021, ⟨10.1016/j.cub.2021.10.007⟩ |
| ISSN: | 1879-0445 0960-9822 |
| DOI: | 10.1016/j.cub.2021.10.007⟩ |
| Popis: | Summary Highly synchronous neuronal assembly activity is deemed essential for cognitive brain function. In theory, such synchrony could coordinate multiple brain areas performing complementary processes. However, cell assemblies have been observed only in single structures, typically cortical areas, and little is known about their synchrony with downstream subcortical structures, such as the striatum. Here, we demonstrate distributed cell assemblies activated at high synchrony (∼10 ms) spanning prefrontal cortex and striatum. In addition to including neurons at different brain hierarchical levels, surprisingly, they synchronized functionally distinct limbic and associative sub-regions. These assembly activations occurred when members shifted their firing phase relative to ongoing 4 Hz and theta rhythms, in association with high gamma oscillations. This suggests that these rhythms could mediate the emergence of cross-structural assemblies. To test for the role of assemblies in behavior, we trained the rats to perform a task requiring cognitive flexibility, alternating between two different rules in a T-maze. Overall, assembly activations were correlated with task-relevant parameters, including impending choice, reward, rule, or rule order. Moreover, these behavioral correlates were more robustly expressed by assemblies than by their individual member neurons. Finally, to verify whether assemblies can be endogenously generated, we found that they were indeed spontaneously reactivated during sleep and quiet immobility. Thus, cell assemblies are a more general coding mechanism than previously envisioned, linking distributed neocortical and subcortical areas at high synchrony. |
| Databáze: | OpenAIRE |
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