Variation in treatment and survival of older patients with non-metastatic breast cancer in five European countries: a population-based cohort study from the EURECCA Breast Cancer Group
| Autor: | Derks, M.G.M., Bastiaannet, E., Kiderlen, M., Hilling, D.E., Boelens, P.G., Walsh, P.M., Eycken, E. van, Siesling, S., Broggio, J., Wyld, L., Trojanowski, M., Kolacinska, A., Chalubinska-Fendler, J., Goncalves, A.F., Nowikiewicz, T., Zegarski, W., Audisio, R.A., Liefers, G.J., Portielje, J.E.A., Velde, C.J.H. van de, EURECCA Breast Canc Grp |
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| Přispěvatelé: | Health Technology & Services Research |
| Jazyk: | angličtina |
| Rok vydání: | 2018 |
| Předmět: |
Cancer Research
Breast surgery medicine.medical_treatment Population Breast Neoplasms Disease-Free Survival Article 03 medical and health sciences 0302 clinical medicine Breast cancer Belgium Epidemiology of cancer Humans Medicine 030212 general & internal medicine Stage (cooking) education Mastectomy Aged Neoplasm Staging Netherlands Aged 80 and over education.field_of_study Relative survival business.industry Age Factors Disease Management Cancer Middle Aged medicine.disease Europe England Oncology 030220 oncology & carcinogenesis Female Poland Neoplasm Recurrence Local business Ireland Demography |
| Zdroj: | British Journal of Cancer, 119(1), 121-129 British Journal of Cancer British journal of cancer, 119(1), 121-129. Nature Publishing Group |
| ISSN: | 0007-0920 |
| Popis: | Background: Older patients are poorly represented in breast cancer research and guidelines do not provide evidence based recommendations for this specific group. We compared treatment strategies and survival outcomes between European countries and assessed whether variance in treatment patterns may be associated with variation in survival. Methods: Population-based study including patients aged ≥ 70 with non-metastatic BC from cancer registries from the Netherlands, Belgium, Ireland, England and Greater Poland. Proportions of local and systemic treatments, five-year relative survival and relative excess risks (RER) between countries were calculated. Results: In total, 236,015 patients were included. The proportion of stage I BC receiving endocrine therapy ranged from 19.6% (Netherlands) to 84.6% (Belgium). The proportion of stage III BC receiving no breast surgery varied between 22.0% (Belgium) and 50.8% (Ireland). For stage I BC, relative survival was lower in England compared with Belgium (RER 2.96, 95%CI 1.30-6.72, P |
| Databáze: | OpenAIRE |
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