Potassium markedly potentiates the effect of veratridine on dopamine release from rat superfused striatal ribbons
| Autor: | Jean-Charles Blanchard, Michel Aubeneau, Alain Boireau, Valérie Olivier, Adam Doble, Jean-Marie Miquet |
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| Rok vydání: | 1992 |
| Předmět: |
Male
medicine.medical_specialty Potassium Dopamine Pharmaceutical Science chemistry.chemical_element Tetrodotoxin In Vitro Techniques chemistry.chemical_compound Internal medicine medicine Animals Pharmacology Membrane potential Veratridine Depolarization Long-term potentiation Drug Synergism Rats Inbred Strains Corpus Striatum Rats Endocrinology chemistry Liberation Calcium Dizocilpine Maleate medicine.drug |
| Zdroj: | The Journal of pharmacy and pharmacology. 44(1) |
| ISSN: | 0022-3573 |
| Popis: | The effects of veratridine-induced depolarization on [3H]dopamine ([3H]DA) release in the presence of a physiological (5 Mm) or a depolarizing (25 Mm) concentration of K+ were studied in-vitro in rat superfused striatal ribbons. A combination of the two depolarizing agents induced a marked potentiation in the overflow of [3H]DA, giving an overall 3- to 5-fold increase in veratridine activity. This potentiation was completely antagonized by tetrodotoxin (100 Nm). These studies indicated that K+-induced depolarization can increase the potency of veratridine in releasing dopamine from terminals. |
| Databáze: | OpenAIRE |
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