Association of early childhood abdominal circumference and weight gain with blood pressure at 36 months of age: secondary analysis of data from a prospective cohort study
| Autor: | C. A. Nowson, S. R. Crozier, S. M. Robinson, K. M. Godfrey, W. T. Lawrence, C. M. Law, C. Cooper, H. M. Inskip, P. Coakley, V. Cox, J. Hammond, T. Horsfall |
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| Jazyk: | angličtina |
| Rok vydání: | 2014 |
| Předmět: |
Male
Pediatrics medicine.medical_specialty Blood Pressure Weight Gain Cohort Studies Abdomen Epidemiology medicine EPIDEMIOLOGY Humans Body Weights and Measures Prospective Studies Early childhood Young adult skin and connective tissue diseases Prospective cohort study Fetus business.industry Research Paediatrics General Medicine medicine.disease Obesity Blood pressure Child Preschool Female sense organs medicine.symptom business Weight gain |
| Zdroj: | BMJ Open |
| Popis: | Objectives To assess whether changes in measures of fat distribution and body size during early life are associated with blood pressure at 36?months of age. Design Analysis of data collected from a prospective cohort study. Setting Community-based investigation in Southampton, UK. Participants 761 children with valid blood pressure measurements, born to women participating in the Southampton Women’s Survey. Primary and secondary outcome measures Anthropometric measurements were collected at 0, 6, 12, 24 and 36?months and conditional changes between the time points calculated. Blood pressure was measured at 36?months. Factors possibly influencing the blood pressure were assessed using linear regression. All independent variables of interest and confounding variables were included in stepwise multiple regression to identify the model that best predicted blood pressure at 36?months. Results Greater conditional gains in abdominal circumference (AC) between 0–6 and 24–36?months were associated with higher systolic and diastolic blood pressures at 36?months (pConclusions Conditional gains in abdominal circumference, particularly within 6?months of birth and in the year preceding measurement, were more positively associated with blood pressure at 36?months than gains in other anthropometric measures. Above-average AC gains in early childhood may contribute to adult hypertension and increased cardiovascular disease risk. |
| Databáze: | OpenAIRE |
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