Conditioned flavor avoidance as a measure of withdrawal in rats chronically exposed to a caffeine solution
| Autor: | Gillian M. Alcolado, Rachel N. Dingle, Sarah E. Dreumont-Boudreau, Vincent M. LoLordo |
|---|---|
| Rok vydání: | 2008 |
| Předmět: |
Male
Time Factors Conditioning Classical Administration Oral Experimental and Cognitive Psychology Pharmacology Drug Administration Schedule Rats Sprague-Dawley Food Preferences Behavioral Neuroscience chemistry.chemical_compound Saccharin Caffeine Avoidance Learning Animals Flavor Behavior Animal food and beverages Rats Substance Withdrawal Syndrome Flavoring Agents chemistry Caffeine withdrawal Taste Anesthesia Central Nervous System Stimulants Reinforcement Psychology |
| Zdroj: | Physiology & Behavior. 95:245-251 |
| ISSN: | 0031-9384 |
| DOI: | 10.1016/j.physbeh.2008.06.008 |
| Popis: | Rats were given 21 days of chronic oral caffeine. A novel flavor (Maintenance CS) was then paired with the continuation of caffeine, and a second flavor (Withdrawal CS) was paired with caffeine removal. Rats avoided the Withdrawal CS, and drank more of the Maintenance CS in a two-bottle test, suggesting that removing caffeine had induced withdrawal. The value of the Maintenance CS was investigated by comparing it to a novel flavor paired with water (Neutral CS). In a series of two-bottle tests, the Maintenance and Neutral CSs were equivalent when pitted against each other, and both were preferred to the Withdrawal CS. These results demonstrate that conditioned flavor avoidance is a useful procedure in assessing caffeine withdrawal, and by inference dependence, produced by chronic oral consumption. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full Text from ScienceDirect