Q fever seroprevalence in parturient women: the EQRUN cross-sectional study on Reunion Island

Autor: Florence Naze, Philippe De Vos, Pierre-Yves Robillard, S. Porcherat, Claudine Somon-Payet, Malik Boukerrou, Laura Atiana, Sandrine Picot, Yoan Mboussou, Patrick Gérardin, Julien Jaubert, Sophie Larrieu
Přispěvatelé: Laboratoire de Bactériologie, Virologie et Parasitologie [Saint-Pierre, La Réunion], Centre Hospitalier Universitaire de La Réunion (CHU La Réunion), Cellule interrégionale d'épidémiologie Océan Indien [Saint-Denis, La Réunion] (CIRE Océan Indien), Institut de Veille Sanitaire (INVS)-Santé publique France - French National Public Health Agency [Saint-Maurice, France], Maternité [Le Tampon, La Réunion], Clinique Durieux [Le Tampon, La Réunion], Maternité [Saint-Pierre, La Réunion], Pôle Femme-Mère-Enfant [CHU La Réunion, Saint-Pierre, La Réunion], Centre Hospitalier Universitaire de La Réunion (CHU La Réunion)-Centre Hospitalier Universitaire de La Réunion (CHU La Réunion), Épidémiologie Clinique [Saint-Pierre, La Réunion], Centre d'Investigation Clinique de La Réunion - INSERM (CIC 1410), Université de La Réunion (UR)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre Hospitalier Universitaire de La Réunion (CHU La Réunion)-Université de La Réunion (UR)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre Hospitalier Universitaire de La Réunion (CHU La Réunion), Pôle Femme-Mère-Enfant [Saint-Pierre, La Réunion], Centre d'Études Périnatales de l'Océan Indien (CEPOI), Université de La Réunion (UR)-Centre Hospitalier Universitaire de La Réunion (CHU La Réunion)-Université de La Réunion (UR)-Centre Hospitalier Universitaire de La Réunion (CHU La Réunion), Processus Infectieux en Milieu Insulaire Tropical (PIMIT), Université de La Réunion (UR)-Institut National de la Santé et de la Recherche Médicale (INSERM)-IRD-Centre National de la Recherche Scientifique (CNRS), The E-Q-RUN program was supported by the APIDOM 2012 grant from the Groupement Interrégional de Recherche Clinique et d’Innovation Sud-Ouest Outre-Mer Hospitalier (GIRCI SOHO)., Bodescot, Myriam, Centre National de la Recherche Scientifique (CNRS)-IRD-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de La Réunion (UR)
Rok vydání: 2020
Předmět:
Cross-sectional study
Immunofluorescence
Miscarriage
Serology
0302 clinical medicine
Seroepidemiologic Studies
Pregnancy
[SDV.MHEP.MI]Life Sciences [q-bio]/Human health and pathology/Infectious diseases
Prevalence
030212 general & internal medicine
Fluorescent Antibody Technique
Indirect
biology
Obstetrics
Middle Aged
Stillbirth
Antibodies
Bacterial
Prevalence proportion ratio
Infectious Diseases
Childbirth
Coxiella burnetii
Parturient woman
[SDV.MHEP.MI] Life Sciences [q-bio]/Human health and pathology/Infectious diseases
Premature Birth
Female
Research Article
Adult
medicine.medical_specialty
Cross sectional study
030231 tropical medicine
Context (language use)
Q fever
[SDV.MHEP.GEO]Life Sciences [q-bio]/Human health and pathology/Gynecology and obstetrics
lcsh:Infectious and parasitic diseases
Young Adult
03 medical and health sciences
Propensity score matching
medicine
Humans
Seroprevalence
lcsh:RC109-216
business.industry
Parturition
medicine.disease
biology.organism_classification
[SDV.MP.BAC]Life Sciences [q-bio]/Microbiology and Parasitology/Bacteriology
Abortion
Spontaneous
[SDV.MHEP.GEO] Life Sciences [q-bio]/Human health and pathology/Gynecology and obstetrics
Cross-Sectional Studies
[SDV.SPEE] Life Sciences [q-bio]/Santé publique et épidémiologie
[SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie
[SDV.MP.BAC] Life Sciences [q-bio]/Microbiology and Parasitology/Bacteriology
business
Reunion
Zdroj: BMC Infectious Diseases
BMC Infectious Diseases, 2020, 20 (1), pp.261. ⟨10.1186/s12879-020-04969-w⟩
BMC Infectious Diseases, Vol 20, Iss 1, Pp 1-7 (2020)
BMC Infectious Diseases, BioMed Central, 2020, 20 (1), pp.261. ⟨10.1186/s12879-020-04969-w⟩
ISSN: 1471-2334
DOI: 10.1186/s12879-020-04969-w
Popis: Background Q fever (Coxiella burnetii infection) has been associated with adverse perinatal outcomes. After investigating the obstetrical importance of Q fever on Reunion island and demonstrating an association between incident Q fever and miscarriage, we conducted a cross-sectional serosurvey to assess the prevalence of Coxiella burnetii infection among parturient women. Methods Between January 9 and July 24, 2014, within the level-4 maternity of Saint Pierre hospital and the level-1 maternity of Le Tampon, we proposed to screen all parturient women for Coxiella burnetii serology. Seropositivity was defined using indirect immunofluorescence for a dilution of phase 2 IgG titre ≥1:64. Further dilutions were chosen to discriminate recent or active infections from past or prevalent infections ( Results Among 1112 parturient women screened for Q fever over this 7-month period, 203 (18.3%) were seropositive. Overall weighted seroprevalence was of 20.1% (95%CI, 17.7–22.5%). Weighted seroprevalence of probable infections was 4.7% (95%CI 3.4–5.9%), while > 90% of positive serologies corresponded to past infections or false positives. Seropositivity was associated with none of the abovementioned adverse perinatal outcomes, whether in unpaired or matched analyses on propensity score. Conclusion The magnitude and the pattern of seroprevalence suggest that Q fever is endemic on Reunion island. In this context, we found no significant contribution of prevalent Coxiella burnetii infection to adverse pregnancy outcomes. Although reassuring, these data put in our endemic context, with a previously demonstrated increased risk of incident Q fever associated miscarriage, encourage us to protect pregnant women against the risk of new infection, periconceptional or early in pregnancy.
Databáze: OpenAIRE
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