Synthesis of N-Fused Triazole–Piperazine–Quinazolinones via One-Pot Tandem Click Reaction and Cross-Dehydrogenative Coupling

Autor:	Nakul C. Maiti, Subhankar Shee, Biswadip Banerji, Saswati Ghosh, Arindam Manna, Ravuri Srinath, Krishnendu Khamaru, Vijay Babu Pathi
Rok vydání:	2021
Předmět:	Tandem Organic Chemistry Triazole Substrate (chemistry) Biochemistry Combinatorial chemistry Coupling reaction Piperazine chemistry.chemical_compound chemistry Atom economy Functional group Click chemistry Physical and Theoretical Chemistry
Zdroj:	Organic Letters. 23:9365-9370
ISSN:	1523-7052 1523-7060
DOI:	10.1021/acs.orglett.1c03435
Popis:	Herein, a one-pot protocol to synthesize tetracyclic triazole-piperazine-quinazolinone-fused N-heterocyclic scaffolds is reported. In this strategy, a tandem approach of two highly efficient synthetic reactions, click and cross-dehydrogentive coupling reactions, with high atom economy were employed to obtain the target N-fused scaffolds. Being highly functional group tolerable, this method has broad substrate scope. Interestingly, some of these derivatives showed strong white solid-state fluorescence.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c5b9ea757abb450d65b53f880963fd21 https://doi.org/10.1021/acs.orglett.1c03435 Zobrazit plný text záznamu