Repair of the in vitro HIV-1-induced immunosuppression and blockade of the generation of functional suppressive CD8 cells by anti-alpha interferon and anti-Tat antibodies
| Autor: | Jean-François Zagury, Jacky Bernard, H. Le Coq, Vida Chams, Bernard Bizzini, Michéle Fouchard, Michael Feldman, A Lachgar, A Astgen, Arsène Burny |
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| Rok vydání: | 1996 |
| Předmět: |
medicine.medical_treatment
Alpha interferon Biology CD8-Positive T-Lymphocytes In Vitro Techniques Peripheral blood mononuclear cell T-Lymphocytes Regulatory Antibodies Immune system Interferon T-Lymphocyte Subsets medicine Immune Tolerance Humans Interferon alfa Pharmacology Acquired Immunodeficiency Syndrome Interferon-alpha Immunosuppression General Medicine Cell culture Immunology Gene Products tat HIV-1 tat Gene Products Human Immunodeficiency Virus CD8 Cell Division medicine.drug |
| Zdroj: | Biomedicinepharmacotherapy = Biomedecinepharmacotherapie. 50(1) |
| ISSN: | 0753-3322 |
| Popis: | Summary The acute human immunodeficiency virus type 1 (HIV-1) infection of activated peripheral blood mononuclear cells (PBMCs) from normal donors results in inhibition of cell proliferation and generation of functional suppressive T cells. Cultured HIV-1 infected PBMCs but not uninfected PBMCs, following irradiation, can inhibit the proliferation of antigen-activated autologous T cells in a dose-dependent way. CD8+ cell subpopulation is responsible for this inhibition. The presence of anti-alpha interferon (IFNα) and anti-Tat antibodies in the culture medium counteracts the HIV-1-induced immunosuppression and prevents the generation of suppressive T cells by these PBMCs. The reported data should have major implications for strategies of AIDS treatment which, in association with antiviral drugs, aim at targetting immune disorders. |
| Databáze: | OpenAIRE |
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