Interferon-α2b-induced STAT3 suppression in myeloid-derived suppressor cells in mycosis fungoides
| Autor: | Michael K. Schowalter, Louis D. Falo, Oleg E. Akilov, Larisa J. Geskin |
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| Rok vydání: | 2018 |
| Předmět: |
STAT3 Transcription Factor
0301 basic medicine Interferon α2b Cancer Research Skin Neoplasms Immunology Interferon alpha-2 Article 03 medical and health sciences Mycosis Fungoides 0302 clinical medicine hemic and lymphatic diseases Humans Immunology and Allergy Medicine STAT3 Mycosis fungoides biology business.industry Myeloid-Derived Suppressor Cells Interferon-alpha medicine.disease 030104 developmental biology Oncology biology.protein Cancer research Myeloid-derived Suppressor Cell business 030215 immunology |
| Zdroj: | Cancer Immunol Immunother |
| ISSN: | 1432-0851 0340-7004 |
| DOI: | 10.1007/s00262-018-2156-6 |
| Popis: | The effect of IFN-α2b on myeloid-derived suppressor cells in cutaneous lymphoma might be mediated via inhibition of STAT3 leading to a decrease of reactive oxygen species and arginine-1 production. |
| Databáze: | OpenAIRE |
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