Human Metapneumovirus Infection Plays an Etiologic Role in Acute Asthma Exacerbations Requiring Hospitalization in Adults
| Autor: | R. Stokes Peebles, Stanley B. Higgins, Robert G. Hamilton, Marie R. Griffin, James E. Crowe, Patricia A. Minton, John V. Williams, Rachel Enriquez, Tina V. Hartert |
|---|---|
| Rok vydání: | 2005 |
| Předmět: |
Adult
Male medicine.medical_specialty Adolescent viruses Severity of Illness Index Article Human metapneumovirus Internal medicine Severity of illness Prevalence Humans Immunology and Allergy Medicine Metapneumovirus Prospective Studies Prospective cohort study Aged Asthma Paramyxoviridae Infections biology Reverse Transcriptase Polymerase Chain Reaction business.industry Respiratory disease virus diseases Odds ratio Middle Aged medicine.disease biology.organism_classification Confidence interval respiratory tract diseases Hospitalization Infectious Diseases Acute Disease Immunology Female business |
| Zdroj: | The Journal of Infectious Diseases. 192:1149-1153 |
| ISSN: | 1537-6613 0022-1899 |
| DOI: | 10.1086/444392 |
| Popis: | We determined the prevalence of human metapneumovirus (hMPV) infection in adults with asthma who were prospectively enrolled after hospitalization for an acute asthma exacerbation. Nasal wash specimens collected at admission and 3 months after discharge were tested for hMPV by real-time reverse-transcription polymerase chain reaction assays. hMPV was detected in 7 (6.9%) of 101 subjects at hospitalization and in 1 (1.3%) of 75 subjects at follow-up (odds ratio, 7 [95% confidence interval, 0.9–312]; P =.03). None of the patients with hMPV infection at hospitalization tested positive at follow-up, strongly suggesting that hMPV plays a direct etiologic role in acute asthma exacerbations. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|