Discovery and characterization of circulating tumor cell clusters in neuroendocrine tumor patients using nanosubstrate-embedded microchips
| Autor: | Na Sun, Yingying Yang, Hui Miao, Peter Redublo, Hongtao Liu, Wenfei Liu, Yen-Wen Huang, Pai-Chi Teng, Ceng Zhang, Ryan Y. Zhang, Matthew Smalley, Peng Yang, Shih-Jie Chou, Kevin Huai, Zhicheng Zhang, Yi-Te Lee, Jasmine J. Wang, Jing Wang, Icy Y. Liang, Tiffany X. Zhang, Dongyun Zhang, Li Liang, Paul S. Weiss, Edwin M. Posadas, Timothy Donahue, J. Randolph Hecht, Martin S. Allen-Auerbach, Emily K. Bergsland, Thomas A. Hope, Renjun Pei, Yazhen Zhu, Hsian-Rong Tseng, Anthony P. Heaney |
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| Rok vydání: | 2021 |
| Předmět: |
Circulating tumor cell clusters
Bioinformatics Biomedical Engineering Biophysics Biosensing Techniques Neoplastic Cells Peptide receptor radionuclide therapy Article Analytical Chemistry Neuroendocrine tumor Clinical Research Circulating Electrochemistry Biomarkers Tumor Nanotechnology Humans Neoplasm Metastasis Cancer screening and diagnosis Tumor Circulating tumor cells General Medicine Neoplastic Cells Circulating 4.1 Discovery and preclinical testing of markers and technologies Detection Neuroendocrine Tumors Nanostructured substrates Biomarkers Biotechnology |
| Zdroj: | Biosens Bioelectron |
| ISSN: | 1873-4235 |
| Popis: | Circulating tumor cell (CTC) clusters are present in cancer patients with severe metastasis, resulting in poor clinical outcomes. However, CTC clusters have not been studied as extensively as single CTCs, and the clinical utility of CTC clusters remains largely unknown. In this study, we aim sought to explore the feasibility of NanoVelcro Chips to simultaneously detect both single CTCs and CTC clusters with negligible perturbation to their intrinsic properties in neuroendocrine tumors (NETs). We discovered frequent CTC clusters in patients with advanced NETs and examined their potential roles, together with single NET CTCs, as novel biomarkers of patient response following peptide receptor radionuclide therapy (PRRT). We observed dynamic changes in both total NET CTCs and NET CTC cluster counts in NET patients undergoing PRRT which correlated with clinical outcome. These preliminary findings suggest that CTC clusters, along with single CTCs, offer a potential non-invasive option to monitor the treatment response in NET patients undergoing PRRT. |
| Databáze: | OpenAIRE |
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