Increased Neurotropic Threat from Burkholderia pseudomallei Strains with a B. mallei–like Variation in the bimA Motility Gene, Australia
| Autor: | Mark Mayo, Catherine M. Rush, Natkunam Ketheesan, Bart J. Currie, EM Parker, Jodie L. Morris, Derek S. Sarovich, Anne Fane, Erin P. Price, Brenda Govan |
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| Jazyk: | angličtina |
| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
Melioidosis Burkholderia pseudomallei Epidemiology lcsh:Medicine Communicable Diseases Emerging Mice Central Nervous System Bacterial Infections bacteria Phagocytes Virulence neurologic Microfilament Proteins neurotropism Infectious Diseases Disease Progression route of infection Microbiology (medical) bimA 030106 microbiology Biology Increased Neurotropic Threat from Burkholderia pseudomallei Strains with a B. mallei–like Variation in the bimA Motility Gene Australia Burkholderia mallei Microbiology lcsh:Infectious and parasitic diseases actin-based motility 03 medical and health sciences Genetic variation medicine Animals Humans lcsh:RC109-216 Allele Gene Research Glanders lcsh:R bacterial infection Australia Genetic Variation medicine.disease biology.organism_classification bacterial infections and mycoses Virology intracellular Disease Models Animal Nasal Mucosa |
| Zdroj: | Emerging Infectious Diseases Emerging Infectious Diseases, Vol 23, Iss 5, Pp 740-749 (2017) |
| ISSN: | 1080-6059 1080-6040 |
| Popis: | These strains have heightened pathogenic potential for rapid dissemination to multiple tissues, including the central nervous system. Neurologic melioidosis is a serious, potentially fatal form of Burkholderia pseudomallei infection. Recently, we reported that a subset of clinical isolates of B. pseudomallei from Australia have heightened virulence and potential for dissemination to the central nervous system. In this study, we demonstrate that this subset has a B. mallei–like sequence variation of the actin-based motility gene, bimA. Compared with B. pseudomallei isolates having typical bimA alleles, isolates that contain the B. mallei–like variation demonstrate increased persistence in phagocytic cells and increased virulence with rapid systemic dissemination and replication within multiple tissues, including the brain and spinal cord, in an experimental model. These findings highlight the implications of bimA variation on disease progression of B. pseudomallei infection and have considerable clinical and public health implications with respect to the degree of neurotropic threat posed to human health. |
| Databáze: | OpenAIRE |
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