The hematopoietic stem-cell niche in health and leukemia

Autor: Simón Méndez-Ferrer, Abel Sanchez-Aguilera
Přispěvatelé: Wellcome Trust, Medical Research Council (Reino Unido), Ministerio de Economía y Competitividad (España), Fundación ProCNIC, Red de Investigación Cooperativa en Terapia Celular (España), Comunidad de Madrid (España), Unión Europea. Comisión Europea, European Hematology Association, Howard Hughes Medical Institute, Méndez-Ferrer, Simón [0000-0002-9805-9988], Apollo - University of Cambridge Repository
Rok vydání: 2016
Předmět:
0301 basic medicine
Cell type
Hematopoietic stem cell niche
education
ENDOTHELIAL NICHES
Leukemia stem cell
MESENCHYMAL STROMAL CELLS
MICROENVIRONMENT
Review
ACUTE MYELOID-LEUKEMIA
Biology
Hematopoietic stem cell
03 medical and health sciences
Cellular and Molecular Neuroscience
Bone Marrow
Tumor Microenvironment
medicine
Animals
Humans
BONE-MARROW NICHE
Molecular Biology
health care economics and organizations
IN-VIVO
Bone marrow microenvironment
Pharmacology
Tumor microenvironment
Leukemia
CHRONIC MYELOGENOUS LEUKEMIA
Stem cell niche
MOUSE MODEL
Cell Biology
Hematopoietic Stem Cells
medicine.disease
3. Good health
Cell biology
SELF-RENEWAL
Haematopoiesis
030104 developmental biology
medicine.anatomical_structure
PROGENITOR CELLS
Hematologic Neoplasms
Immunology
Neoplastic Stem Cells
Molecular Medicine
Bone marrow
Stem cell
Zdroj: Repisalud
Instituto de Salud Carlos III (ISCIII)
Cellular and Molecular Life Sciences
ISSN: 1420-9071
1420-682X
DOI: 10.1007/s00018-016-2306-y
Popis: Research in the last decade has shown that hematopoietic stem cells (HSCs) interact with and are modulated by a complex multicellular microenvironment in the bone marrow, which includes both the HSC progeny and multiple non-hematopoietic cell types. Intense work is gradually throwing light on the composition of the HSC niche and the molecular cues exchanged between its components, which has implications for HSC production, maintenance and expansion. In addition, it has become apparent that bidirectional interactions between leukemic cells and their niche play a previously unrecognized role in the initiation and development of hematological malignancies. Consequently, targeting of the malignant niche holds considerable promise for more specific antileukemic therapies. Here we summarize the latest insights into HSC niche biology and recent work showing multiple connections between hematological malignancy and alterations in the bone marrow microenvironment. We thank members of the SM-F group for helpful discussions. This work was supported by core support grants from the Wellcome Trust and MRC to the Cambridge Stem Cell Institute, the Spanish Ministry of Economy and Competitiveness (SAF-2011-30308), Pro-CNIC Foundation, Severo Ochoa Center of Excellence award SEV-2015-0505 to CNIC, TerCel (Spanish Cell Therapy Network), Ramon y Cajal Program grants RYC-2011-09726 to AS-A and RYC-2009-04703 to SM-F), Marie Curie Career Integration Program grants (FP7-PEOPLE-2011-RG-294262/294096) to AS-A and SM-F; and a ConSEPOC-Comunidad de Madrid grant (S2010/BMD-2542) and Horizon2020 (ERC-2014-CoG-64765 grant to SM-F. This research was partly funded by a European Hematology Association Research Fellowship awarded to AS-A and an International Early Career Scientist Grant from the Howard Hughes Medical Institute to SM-F. Sí
Databáze: OpenAIRE
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