Eosinophilia and granulocytic dysplasia terminating in acute myeloid leukaemia after 24 years
| Autor: | K. van Lom, Bob Löwenberg, J. K. Doorduijn |
|---|---|
| Rok vydání: | 1996 |
| Předmět: |
Adult
Male Pathology medicine.medical_specialty Myeloid Trisomy Trisomy 8 hemic and lymphatic diseases Eosinophilia Medicine Humans Aged business.industry Brain Neoplasms Cytogenetics Hematology Middle Aged medicine.disease Leukemia Leukemia Myeloid Acute medicine.anatomical_structure Cell Transformation Neoplastic Dysplasia Karyotyping Immunology Disease Progression Sarcoma medicine.symptom business Chromosomes Human Pair 8 |
| Zdroj: | British journal of haematology. 95(3) |
| ISSN: | 0007-1048 |
| Popis: | Eosinophilia of variable duration, and subsequent progression to granulocytic sarcoma and acute myeloid leukaemia, has been infrequently reported in the literature. We report a patient with eosinophilia and normal cytogenetics who, after 24 years, showed transformation to a granulocytic sarcoma of the brain. Haematological counts were normal but the marrow revealed the cytogenetic abnormality trisomy 8 in 25% of mitoses. Subsequently an AML-M2 developed, showing a complex karyotype including the trisomy 8 in all metaphases. FISH analysis combined with cytological examination identified the trisomy 8 in blasts, eosinophils and dysplastic granulocytes only. Thus progressive leukaemic transformation selectively involved the myeloid compartment. |
| Databáze: | OpenAIRE |
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