Inspiratory muscle dysfunction and unexplained dyspnea in systemic lupus erythematosus
| Autor: | Loreto Massardo, Sergio Jacobelli, Rodrigo Moreno, Santiago J. Rivero, Carmen Lisboa |
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| Rok vydání: | 1985 |
| Předmět: |
Adult
Male medicine.medical_specialty Adolescent Diaphragm Physical Exertion Vital Capacity Immunology Pulmonary compliance Pathogenesis Rheumatology Internal medicine medicine Humans Lupus Erythematosus Systemic Immunology and Allergy Pharmacology (medical) Lung volumes In patient Lung Compliance business.industry Muscles Respiration Transdiaphragmatic pressure Quiet breathing Inspiratory muscle Middle Aged Muscle antibody respiratory tract diseases Oxygen Dyspnea Inhalation Cardiology Female Lung Volume Measurements business |
| Zdroj: | Arthritis & Rheumatism. 28:781-788 |
| ISSN: | 1529-0131 0004-3591 |
| DOI: | 10.1002/art.1780280709 |
| Popis: | The role of inspiratory muscle dysfunction in lung volume restriction and unexplained dyspnea was studied in 16 consecutive patients with systemic lupus erythematosus. Maximal mouth inspiratory pressure (PIM) and maximal transdiaphragmatic pressure (Pdi max) were measured. Pdi and its components were determined during quiet breathing. No significant association was found between the activity of the disease, several serologic markers, and the inspiratory muscle dysfunction. No specific anti-skeletal muscle antibody was found in these patients. Significant correlations were found between the degree of dyspnea and PIM (r = -0.69, P less than 0.01) and Pdi max (r = -0.75, P less than 0.001); however, dyspnea did not correlate with specific lung compliance. Vital capacity correlated significantly with the degree of dyspnea (r = -0.813, P less than 0.001) and with Pdi max (r = 0.544, P less than 0.05). No correlation was found between vital capacity and specific lung compliance. We conclude that inspiratory muscle dysfunction can be an important mechanism in the pathogenesis of the lung volume restriction and dyspnea in patients with systemic lupus erythematosus. |
| Databáze: | OpenAIRE |
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