Obstructive sleep apnea may increase the risk of Alzheimer's disease

Autor: Jerzy Mosiewicz, Paweł Kiciński, Maciej Zakrzewski, Wojciech Myśliński, Sylwia Przybylska-Kuć, Grzegorz Dzida, Andrzej Dybała, Andrzej Prystupa, Barbara Mosiewicz-Madejska
Rok vydání: 2019
Předmět:
Male
0301 basic medicine
Pulmonology
Apnea
Physiology
Pathogenesis
Polysomnography
Alzheimer's Disease
Pathology and Laboratory Medicine
Nervous System
Severity of Illness Index
Gastroenterology
Body Mass Index
Hypoxemia
0302 clinical medicine
Risk Factors
Medicine and Health Sciences
Hypoxia
Cerebrospinal Fluid
Sleep Apnea
Obstructive
Multidisciplinary
medicine.diagnostic_test
Sleep apnea
Neurodegenerative Diseases
Middle Aged
Prognosis
Body Fluids
Blood
Neurology
Medicine
Female
Anatomy
medicine.symptom
Hypopnea
Research Article
medicine.medical_specialty
Sleep Apnea
Science
03 medical and health sciences
stomatognathic system
Alzheimer Disease
Internal medicine
Mental Health and Psychiatry
Medical Hypoxia
Severity of illness
medicine
Humans
Amyloid beta-Peptides
business.industry
Biology and Life Sciences
Cell Biology
Hypoxia (medical)
medicine.disease
nervous system diseases
respiratory tract diseases
Obstructive sleep apnea
030104 developmental biology
Dementia
Sleep Disorders
business
030217 neurology & neurosurgery
Zdroj: PLoS ONE
PLoS ONE, Vol 14, Iss 9, p e0221255 (2019)
ISSN: 1932-6203
DOI: 10.1371/journal.pone.0221255
Popis: ObjectivesAmyloid-β 1-40 (Aβ 1-40) and amyloid-β 1-42 (Aβ 1-42) are the proteins known to be involved in the pathogenesis of Alzheimer's disease (AD)-the most common cause of dementia in the elderly. Hypoxia is suspected to be one of conditions associated with Aβ plasma level increase. A common reason of hypoxia is obstructive sleep apnea (OSA), characterized by recurrent episodes of apnea.AimThe aim of the study was to evaluate plasma Aβ 1-40 and Aβ 1-42 concentrations in patients with OSA.MethodsPatients with suspected OSA (n = 112) underwent polygraphic examinations Patients with confirmed OSA (n = 81) showed apnea/hypopnea index greater than or equal to 5. Mild and moderate form of the disease was defined when AHI was 5-30 (n = 38, OSA+), severe-when AHI was >30 (n = 43, OSA++). Individuals with AHIResultsAβ 1-40 concentrations in OSA++ (191.1 pg/ml) group was significantly (pConclusionIn patients with severe OSA Aβ 1-40 plasma concentrations are significantly higher compared with OSA- and OSA+ and seem to be related to hypoxia severity, which may indicate increased risk of AD development in this group of patients.
Databáze: OpenAIRE
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