Electrochemical behaviour of acemetacin
| Autor: | J.López Palacios, P.Sánchez Batanero, J. Arcos |
|---|---|
| Rok vydání: | 1988 |
| Předmět: |
Polarography
Clinical Biochemistry Inorganic chemistry Acemetacin Analytical technique Pharmaceutical Science Electrochemistry Analytical Chemistry Coulometry chemistry.chemical_compound chemistry Drug Discovery Linear sweep voltammetry medicine Molecule Spectroscopy Derivative (chemistry) medicine.drug |
| Zdroj: | Journal of Pharmaceutical and Biomedical Analysis. 6:963-968 |
| ISSN: | 0731-7085 |
| DOI: | 10.1016/0731-7085(88)80117-1 |
| Popis: | Acemetacin or l-(4-chlorobenzoyl)-5-methoxy-2-methyl-1H-indole-3-acetic acid carboxymethyl ester is an efficient anti-inflammatory compound, and a derivative of indomethacin. Synthesis [l, 21, metabolism and pharmacokinetics [3, 41 of acemetacin have been well established. In the field of quaptitative analysis of acemetacin, thin layer chromatographic [5], liquid chromatographic [6], UV-spectroscopic [5], and fluorimetric [5] methods have been reported. No references on its electrochemical behaviour and related analytical methods have been found. However the electroactivity of acemetacin can be predicted because one reducible C = 0 group is present in the molecule. The general model for the reduction of amides to a-hydroxyamines can be applied in this case. The aim of this work was to verify that possibility and to develop some polarographic quantitative procedures based on it. In the examination of the nature and features of the electrodic process tast polarography, linear sweep voltammetry and potential controlled coulometry were used; as a quantitative analytical technique, pulse polarography was also considered. |
| Databáze: | OpenAIRE |
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