Review of IgG4-related disease
| Autor: | Elsa María Alonso-Muñoz, Raquel Sánchez-Oro, Lidia Martí Romero |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
030203 arthritis & rheumatology
Pathology medicine.medical_specialty Bile duct business.industry Lymph duct Disease medicine.disease 03 medical and health sciences 0302 clinical medicine medicine.anatomical_structure 030220 oncology & carcinogenesis Major Salivary Gland parasitic diseases medicine Humans IgG4-related disease Immunoglobulin G4-Related Disease Pancreas business Algorithms Immunostaining Autoimmune pancreatitis |
| Zdroj: | Gastroenterología y Hepatología (English Edition). 42:638-647 |
| ISSN: | 2444-3824 |
| DOI: | 10.1016/j.gastre.2019.08.002 |
| Popis: | IgG4-related disease is a fibrous-inflammatory process related to immunomodulation. The most commonly affected organs are: the pancreas, bile duct, major salivary glands, lacrimal glands, retroperitoneum and lymphatic ducts. In recent decades, this disease has been recognised as a systemic disorder that includes many single organ disorders, previously unrelated and known as independent entities. The common characteristics shared by the different entities that make up the IgG4-related disease are: raised serum IgG4 levels, alterations in the imaging tests with neoplastic-like swelling of the affected organs, specific histopathological characteristics and in immunostaining, as well as good response to treatment with glucocorticoids. In this work, we will review this pathology with a special emphasis on the characteristics of autoimmune pancreatitis, sclerosing cholangitis related to IgG4 and the involvement of the retroperitoneum, mesenterium and the digestive tract. |
| Databáze: | OpenAIRE |
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