Beyond eosinophilia: inflammatory patterns in patients with asthma
| Autor: | Miriam Montzerrat Flores-Razo, Angie Bedolla-Pulido, Martín Bedolla-Barajas, Juan Mariscal-Castro, Dante Daniel Hernández-Colín, Jaime Morales-Romero, Désirée Larenas-Linnemann |
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| Rok vydání: | 2020 |
| Předmět: |
Pulmonary and Respiratory Medicine
Adult Blood Platelets medicine.medical_specialty Neutrophils Inflammation Gastroenterology 03 medical and health sciences Leukocyte Count 0302 clinical medicine Internal medicine Healthy control Eosinophilia medicine Immunology and Allergy Asthmatic patient Humans In patient 030212 general & internal medicine Lymphocytes Asthma Retrospective Studies Adult patients business.industry medicine.disease Peripheral blood Eosinophils Cross-Sectional Studies 030228 respiratory system Case-Control Studies Pediatrics Perinatology and Child Health medicine.symptom business |
| Zdroj: | The Journal of asthma : official journal of the Association for the Care of Asthma. 59(2) |
| ISSN: | 1532-4303 |
| Popis: | Background: Recently, inflammatory cell ratios have gained importance as useful indicators in the categorization of asthma.Objective: We compared the concentration of white blood cells in peripheral blood, as well as their respective inflammatory cell ratios, between patients with asthma and a healthy control group.Methods: We performed cross-sectional analyses of the data obtained from 53 adult patients with asthma and 109 adult controls. In our study, we estimated and compared the following inflammatory cell ratios: Neutrophil-Lymphocyte Ratio (NLR), Eosinophil-Lymphocyte Ratio (ELR), Eosinophil-Neutrophil Ratio (ENR), Eosinophil-Monocyte Ratio (EMR), and Platelet-Lymphocyte Ratio (PLR). The magnitude of association was quantified with the odds ratio.Results: In both groups, the average age was 33 years. In asthmatic patients, we obtained the following results: eosinophils ≥ 400 cells/µl, accounted for 37.7%; basophils ≥ 110 cells/µl, comprised 37.7%; and monocytes < 320 cells/µl, reached 11.3%. In the control group, the results were as follows: 4.6%, 9.2% and 0.9%, respectively. When compared to the control group, asthmatic patients had higher odds of eosinophils ≥ 400 cells/µl (OR = 12.61, p |
| Databáze: | OpenAIRE |
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