Cannabis and tolerance
| Autor: | J. G. Ramaekers, J. H. van Wel, D. B. Spronk, S. W. Toennes, K. P. C. Kuypers, E. L. Theunissen, R. J. Verkes |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2016 |
| Předmět: |
Adult
Male Marijuana Abuse Adolescent Article Drug Users Cocaine-Related Disorders Executive Function Habits Young Adult Cognition Cocaine Double-Blind Method Humans Attention Dronabinol Stress-related disorders DCN: Donders Centre for Neurosciences [Radboudumc 13] GeneralLiterature_REFERENCE(e.g. dictionaries encyclopedias glossaries) Netherlands Multidisciplinary Cross-Over Studies Drug Tolerance Mental Status and Dementia Tests Acute Disease Impulsive Behavior Female Erratum Psychomotor Performance |
| Zdroj: | Scientific Reports Scientific Reports, 6, 31939 Scientific Reports, 6, pp. 31939 |
| ISSN: | 2045-2322 |
| DOI: | 10.1038/srep31939 |
| Popis: | Cannabis use history as predictor of neurocognitive response to cannabis intoxication remains subject to scientific and policy debates. The present study assessed the influence of cannabis on neurocognition in cannabis users whose cannabis use history ranged from infrequent to daily use. Drug users (N = 122) received acute doses of cannabis (300 μg/kg THC), cocaine HCl (300 mg) and placebo. Cocaine served as active control for demonstrating neurocognitive test sensitivity. Executive function, impulse control, attention, psychomotor function and subjective intoxication were significantly worse after cannabis administration relative to placebo. Cocaine improved psychomotor function and attention, impaired impulse control and increased feelings of intoxication. Acute effects of cannabis and cocaine on neurocognitive performance were similar across cannabis users irrespective of their cannabis use history. Absence of tolerance implies that that frequent cannabis use and intoxication can be expected to interfere with neurocognitive performance in many daily environments such as school, work or traffic. |
| Databáze: | OpenAIRE |
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