Aichi Virus IgG Seroprevalence in Tunisia Parallels Genomic Detection and Clinical Presentation in Children with Gastroenteritis
| Autor: | Pierre Pothier, Mouna Hassine, S. Chouchane, Hakima Gharbi-Khelifi, Nabil Sakly, Khira Sdiri-Loulizi, Ludwig-Serge Aho, Zaidoun Aouni, Mohamed Neji-Guédiche, Jean-Baptiste Bour, Katia Ambert-Balay, Mahjoub Aouni, Maha Mastouri |
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| Rok vydání: | 2010 |
| Předmět: |
Adult
Diarrhea Microbiology (medical) Kobuvirus Tunisia Adolescent Fever Vomiting viruses Clinical Biochemistry Immunology Enzyme-Linked Immunosorbent Assay Genome Viral Antibodies Viral Virus Immunoglobulin G Young Adult Seroepidemiologic Studies Humans Immunology and Allergy Medicine Seroprevalence Child biology business.industry Age Factors virus diseases Middle Aged biology.organism_classification Virology Gastroenteritis Immunoglobulin M biology.protein Microbial Immunology medicine.symptom Antibody business Aichi virus |
| Zdroj: | Clinical and Vaccine Immunology. 17:1111-1116 |
| ISSN: | 1556-679X 1556-6811 |
| Popis: | Aichi virus has been described as a novel causative agent of gastroenteritis in humans. In this study, we report the seroprevalence distribution of Aichi virus in Tunisia. A panel of 1,000 sera was screened by applying an enzyme-linked immunosorbent assay for immunoglobulin G specific for Aichi virus. A considerable prevalence (92%) of antibody to Aichi virus was found across all age groups. The specific anti-Aichi virus antibodies increased with age, from a high rate (68.8%) in children under 10 years old to about 100% in persons more than 60 years old. We found a statistically significant increase in levels of antibody to Aichi virus according to the age of patients. Immunoglobulin M antibodies were detected among five children. A high frequency of Aichi virus monoinfections in hospitalized children with severe gastroenteritis was previously observed in Tunisia. Aichi virus causes diarrhea with dehydration, fever, and vomiting. This work is the first to establish a correlation between the high seroprevalence of specific Aichi virus antibodies, clinical presentation, and a high frequency of isolation of Aichi virus by genomic characterization in stools of children suffering from gastroenteritis. Our data show the importance and emerging character of Aichi virus in the viral etiology of pediatric gastroenteritis. |
| Databáze: | OpenAIRE |
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