Protective Effect of the MCP-1 Gene Haplotype against Schizophrenia
| Autor: | Oumaima Inoubli, Mohsen Hassine, Sihem Ben Fredj, Besma Bel Hadj Jrad, Bochra Ben mohamed, Lotfi Gaha, Hana Saoud |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
Adult
Male 0301 basic medicine Chemokine Tunisia Adolescent Article Subject lcsh:Medicine behavioral disciplines and activities General Biochemistry Genetics and Molecular Biology 03 medical and health sciences 0302 clinical medicine Genetic variation Prevalence Humans Medicine Allele Gene Alleles Chemokine CCL2 Neuroinflammation Aged General Immunology and Microbiology biology business.industry Haplotype lcsh:R Genetic Variation General Medicine Middle Aged medicine.disease Minor allele frequency 030104 developmental biology Haplotypes Schizophrenia Immunology biology.protein Female business 030217 neurology & neurosurgery Research Article |
| Zdroj: | BioMed Research International, Vol 2019 (2019) BioMed Research International |
| ISSN: | 2314-6133 |
| DOI: | 10.1155/2019/4042615 |
| Popis: | While cytokines and their genetic variants have been intensively studied in schizophrenia, little attention has been focused on chemokines in the last years. The monocyte chemoattractant protein 1 (MCP-1) is known to attract peripheral monocytes to the brain during an inflammatory reaction and to affect the T helper (Th) cell development by stimulating Th2 polarization. Owing to the neuroinflammation in schizophrenia and the variable level of MCP-1 in these patients’ sera, we proposed to analyze the impact of functional genetic variants of the MCP-1 gene (MCP-1-2518A/G (rs1024611), MCP-1-362G/C (rs2857656), and MCP-1 int1del554-567 (rs3917887)) in schizophrenic patients. We conducted a case-control study on a Tunisian population composed of 200 patients and 200 controls using RFLP-PCR. Our results indicated that the minor alleles (-2518G and Del554-567) were significantly more prevalent in controls than in patients (P=0.001/adjusted OR = 0.42, P=0.04/adjusted OR = 0.64), whereas, for -362C minor allele, increased risk of schizophrenia was revealed (P=0.001, adjusted OR = 2.38). In conclusion, we have identified the haplotype combination -2581G/-362G/int1del554-567 that could mediate protection against schizophrenia (P=0.0038, OR = 0.19) and the effect could result more strongly from the MCP-1 -2582G with -362G variants, whereas the effect of int1del554-567 may in part be explained by its LD with -362. |
| Databáze: | OpenAIRE |
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