Two Cases of Corneal Perforation after Oral Administration of Nonsteroidal Anti-Inflammatory Drugs: Oral Nsaid-Induced Corneal Damage
| Autor: | Kyoko Matsushita, Kazuo Okamoto, Ikuya Masuda, Toshihiko Matsuo, Hiroshi Ohtsuki |
|---|---|
| Rok vydání: | 2010 |
| Předmět: |
medicine.medical_specialty
medicine.drug_class Administration Oral Anti-inflammatory Arthritis Rheumatoid Cornea 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Oral administration medicine Humans Aged Mixed Connective Tissue Disease Wound Healing Nonsteroidal Corneal Damage Corneal Perforation business.industry Anti-Inflammatory Agents Non-Steroidal General Medicine Middle Aged Corneal perforation medicine.disease digestive system diseases eye diseases Surgery Ophthalmology medicine.anatomical_structure chemistry Anesthesia 030221 ophthalmology & optometry Female sense organs business 030217 neurology & neurosurgery Follow-Up Studies |
| Zdroj: | European Journal of Ophthalmology. 20:454-456 |
| ISSN: | 1724-6016 1120-6721 |
| DOI: | 10.1177/112067211002000230 |
| Popis: | PURPOSE To report 2 cases of corneal perforation associated with the use of oral nonsteroidal anti-inflammatory drugs (NSAIDs). METHODS In a 62-year-old woman and a 79-year-old woman, corneal perforation occurred after 7 days and 5 months of oral NSAIDs administration, respectively. RESULTS After NSAIDs were discontinued, the cornea epithelialized and the anterior chamber formed within 14 and 10 days, respectively. CONCLUSIONS It is well known that topical NSAIDs cause corneal perforation. Observations in the present cases suggest that the oral administration of NSAIDs may also cause corneal damage, and hence, medical professionals should consider the risk of damage to the cornea when administering these drugs orally. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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