Superficial siderosis – mechanism of disease: an alternative hypothesis
| Autor: | Shree Gopal Sharma, Santo Longo, Sudip Nanda |
|---|---|
| Rok vydání: | 2010 |
| Předmět: |
Male
Pathology medicine.medical_specialty Siderosis Ataxia medicine.diagnostic_test business.industry Clinical Biochemistry Central nervous system Magnetic resonance imaging General Medicine Disease Middle Aged Subarachnoid Hemorrhage Bleed medicine.disease Magnetic Resonance Imaging Superficial siderosis Myelopathy medicine.anatomical_structure medicine Humans Subarachnoid space medicine.symptom business |
| Zdroj: | Annals of Clinical Biochemistry: International Journal of Laboratory Medicine. 47:275-278 |
| ISSN: | 1758-1001 0004-5632 |
| DOI: | 10.1258/acb.2010.009226 |
| Popis: | Superficial siderosis is an increasingly common diagnosis due to advances in imaging. Resulting from the presence of blood in the subarachnoid space, it leads to progressively debilitating ataxia, deafness and myelopathy. Magnetic resonance imaging has revolutionized diagnosis and management of this condition. In one-third of patients with this diagnosis, no subarachnoid bleed can be identified. A lack of sensitivity in our ability to detect subarachnoid bleed is a possible explanation in this group of patients. A novel approach would be to consider defects in the body's defense against intracranial iron overload as a possible cause of this disease. A disproportionately few patients develop superficial siderosis compared with the number who develop subarachnoid bleed from various clinical conditions. Normal physiological protective mechanisms exist in the central nervous system to protect it from damage by blood, haeme or free iron. Deficiency and defect of these protective mechanisms can provide insight into the pathogenetic mechanism of the group of patients where no subarachnoid haemorrhage is identified. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|