Does influenza A infection increase oxidative damage?
| Autor: | Raymond C.S. Seet, Erle C.H. Lim, Mary P. E. Ng, Barry Halliwell, Leonard L.L. Yeo, Amy M.L. Quek, Wai Mun Loke, Jetty C Y Lee |
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| Rok vydání: | 2014 |
| Předmět: |
Adult
Male medicine.medical_specialty Physiology Clinical Biochemistry medicine.disease_cause Biochemistry Acute illness Pathogenesis Oxidative damage Internal medicine Clinical information Hydroxyeicosatetraenoic Acids Influenza Human medicine Influenza A virus Humans Neuroprostanes Molecular Biology Fatigue General Environmental Science F2-Isoprostanes business.industry Mean age Influenza a Cell Biology Myalgia Arthralgia Oxidative Stress C-Reactive Protein Cohort Immunology General Earth and Planetary Sciences Female business Oxidation-Reduction Biomarkers |
| Zdroj: | Antioxidantsredox signaling. 21(7) |
| ISSN: | 1557-7716 |
| Popis: | Considerable data implicate oxidative damage in influenza pathogenesis. We examined temporal changes in oxidative damage using accurate biomarkers in an adult cohort with acute influenza infection and their relationships with clinical parameters. Clinical information and blood samples were collected during their acute illness and 3 months later. A fatigue questionnaire was administered 3 months following influenza infection. Thirty-five patients (mean age, 34 years) with polymerase chain reaction-confirmed influenza A infection were included; all patients returned for follow-up assessments. Adjusted levels of plasma F2-isoprostanes, total hydroxyeicosatetraenoic products (HETEs), 7β-hydroxycholesterol and 7-ketocholesterol, serum gamma-glutamyltransferase, and high-sensitivity C-reactive protein (hsCRP) were increased during the acute illness compared with age-matched controls. Despite clinical recovery, levels of these biomarkers remained higher at month 3 compared with controls. A proportion of patients had persistent symptoms such as fatigue (23%), myalgia (14%), and arthralgia (11%) at month 3. Patients with significant fatigue had higher baseline levels of plasma F2-isoprostanes, F4-neuroprostanes, and total HETEs compared to those without fatigue. By contrast, patients with persistent arthralgia and myalgia had higher baseline levels of serum hsCRP compared to those without these symptoms. Our observations lead to the hypothesis that oxidative damage participates in the pathogenesis of influenza infection and postinfectious fatigue. |
| Databáze: | OpenAIRE |
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