Toxicity Assessment and Selective Leaching Characteristics of Cu-Al-Ni Shape Memory Alloys in Biomaterials Applications
| Autor: | Jin-Xiang Lin, Bor-Yann Chen, Shih-Hang Chang |
|---|---|
| Rok vydání: | 2016 |
| Předmět: |
Materials science
Biomedical Engineering Biophysics Bioengineering Nanotechnology 02 engineering and technology General Medicine Shape-memory alloy 010402 general chemistry 021001 nanoscience & nanotechnology 01 natural sciences 0104 chemical sciences Biomaterials Damping capacity Nickel Pseudoelasticity Alloys Escherichia coli Selective leaching 0210 nano-technology Copper Aluminum |
| Zdroj: | Journal of Applied Biomaterials & Functional Materials. 14:59-64 |
| ISSN: | 2280-8000 |
| DOI: | 10.5301/jabfm.5000245 |
| Popis: | Background Cu-Al-Ni shape memory alloys (SMAs) possess two-way shape memory effects, superelasticity, and damping capacity. Nonetheless, Cu-Al-Ni SMAs remain promising candidates for use in biomedical applications, as they are more economical and machinable than other SMAs. Ensuring the biocompatibility of Cu-Al-Ni SMAs is crucial to their development for biomedical applications. Therefore, this study aimed to assess the toxicity of Cu-Al-Ni SMAs using a Probit dose–response model and augmented simplex design. Methods In this study, the effects of Cu2+, Al3+ and Ni2+ metal ions on bacteria ( Escherichia coli DH5α) using Probit dose–response analysis and augmented simplex design to assess the actual toxicity of the Cu-Al-Ni SMAs. Results Extraction and repetition of Escherichia coli DH5α solutions with high Cu2+ ion concentrations and 30-hour incubation demonstrated that Escherichia coli DH5α was able to alter its growth mechanisms in response to toxins. Metal ions leached from Cu-Al-Ni SMAs appeared in a multitude of compositions with varying degrees of toxicity, and those appearing close to a saddle region identified in the contour plot of the augmented simplex model were identified as candidates for elevated toxicity levels. When the Cu-13.5Al-4Ni SMA plate was immersed in Ringer's solution, the selective leaching rate of Ni2+ ions far exceeded that of Cu2+ and Al3+. The number of Cu2+, Al3+ and Ni2+ ions leached from Cu-Al-Ni SMAs increased with immersion time; however, at higher ratios, toxicity interactions among the metal ions had the effect of gradually reducing overall toxicity levels with regard to Escherichia coli DH5α. Conclusions The quantities of Cu2+, Al3+ and Ni2+ ions leached from the Cu-13.5Al-4Ni SMA plate increased with immersion time, the toxicity interactions associated with these compositions reduced the actual toxicity to Escherichia coli DH5α. |
| Databáze: | OpenAIRE |
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