Effect of inhaled PGE2 on exercise-induced bronchoconstriction in asthmatic subjects
| Autor: | Patrick J. Manning, K L Woolley, E. Melillo, Paul M. O'Byrne, Richard M. Watson |
|---|---|
| Rok vydání: | 1994 |
| Předmět: |
Adult
Male Pulmonary and Respiratory Medicine Bronchoconstriction Prostaglandin Physical exercise Critical Care and Intensive Care Medicine Placebo Bronchial Provocation Tests Dinoprostone chemistry.chemical_compound Double-Blind Method Forced Expiratory Volume Administration Inhalation medicine Humans Prostaglandin E2 Methacholine Chloride Asthma Inhalation business.industry medicine.disease Asthma Exercise-Induced chemistry Anesthesia Female Methacholine medicine.symptom business medicine.drug |
| Zdroj: | American Journal of Respiratory and Critical Care Medicine. 149:1138-1141 |
| ISSN: | 1535-4970 1073-449X |
| DOI: | 10.1164/ajrccm.149.5.8173753 |
| Popis: | Previous studies have suggested that the endogenous release of inhibitory prostanoids limits the bronchoconstrictor response to repeated exercise. The aim of our study was to determine whether inhaled prostaglandin (PG)E2 attenuates exercise-induced bronchoconstriction or methacholine airway responsiveness in asthmatic subjects. Eight subjects with mild stable asthma and exercise bronchoconstriction were studied on 4 separate days, 48 h apart. Subjects inhaled PGE2 or placebo in a randomized, crossover, double-blind fashion, 30 min prior to an exercise challenge or a methacholine challenge. PGE2 inhalation significantly attenuated exercise bronchoconstriction. The mean maximal %fall in FEV1 after exercise was 26% (SEM 3.7%) after placebo, and was 9.7% (SEM 2.7%) after PGE2 (p < 0.001). PGE2 also significantly reduced the duration of exercise bronchoconstriction (p = 0.034). However, PGE2 did not significantly attenuate methacholine airway responsiveness. The geometric mean methacholine provocative concentration causing a 20% fall in FEV1 (PC20) was 0.77 (%SEM 1.48) after placebo day, and 1.41 (%SEM 2.20) after PGE2 (p = 0.30). These results demonstrate that inhaled PGE2 markedly attenuates exercise bronchoconstriction in asthmatic subjects and suggest that this effect is not occurring through functional antagonism of airway smooth muscle. |
| Databáze: | OpenAIRE |
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