First Evidence of Cardiac Stem Cells From the Left Ventricular Apical Tip in Patients With Left Ventricular Assist Device Implantation
| Autor: | Piero Tanganelli, S. Censini, Roberta Romagnoli, Carlo Sassi, Sonia Bernazzali, Francesco Emmanuel Cassano, C. Di Tommaso, Valeria Curci, Francesca Ietta, G. Droandi, Guido Sani, Marta Focardi, Alessandro Mugelli, Matteo Cameli, Aleksander Dokollari, Eufemia Incampo, G. Marotta, Francesca Maria Righini, Luana Paulesu, S. Sparla, Damiana Tacchini, Massimo Maccherini, Laura Sartiani, Sergio Mondillo |
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| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
medicine.medical_specialty Biopsy Heart Ventricles medicine.medical_treatment Myocardial Ischemia Speckle tracking echocardiography 030204 cardiovascular system & hematology Prosthesis Implantation 03 medical and health sciences 0302 clinical medicine Fibrosis Internal medicine medicine Humans Cardiac Surgical Procedures Heart Failure Transplantation Ischemic cardiomyopathy medicine.diagnostic_test business.industry Myocardium Stem Cells medicine.disease Surgery 030104 developmental biology Echocardiography Ventricular assist device Heart failure Cardiology Heart-Assist Devices Stem cell business |
| Zdroj: | Transplantation Proceedings. 48:395-398 |
| ISSN: | 0041-1345 |
| Popis: | Background Recent studies have challenged the dogma that the adult heart is a postmitotic organ and raise the possibility of the existence of resident cardiac stem cells (CSCs). Our study aimed to explore if these CSCs are present in the “ventricular tip” obtained during left ventricular assist device (LVAD) implantation from patients with end-stage heart failure (HF) and the relationship with LV dysfunctional area extent. Methods Four consecutive patients with ischemic cardiomyopathy and end-stage HF submitted to LVAD implantation were studied. The explanted “ventricular tip” was used as a sample of apical myocardial tissue for the pathological examination. Patients underwent clinical and echocardiographic examination, both standard transthoracic echocardiography (TTE) and speckle tracking echocardiography (STE), before LVAD implantation. Results All patients presented severe apical dysfunction, with apical akinesis/diskinesis and very low levels of apical longitudinal strain (−3.5 ± 2.9%). Despite this, the presence of CSCs was demonstrated in pathological myocardial samples of “ventricular tip” in all 4 of the patients. It was found to be a mean of 6 c-kit cells in 10 fields magnification 40×. Conclusions Cardiac stem cells can be identified in the LV apical segment of patients who have undergone LVAD implantation despite LV apical fibrosis. |
| Databáze: | OpenAIRE |
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