Is there a relation between Murine double minute 2 T309G polymorphism and lung cancer risk in the Turkish population?
| Autor: | Musa Sari, Ayca Tas, Meral Yilmaz, Yavuz Silig, Turgut Kacan |
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| Přispěvatelé: | [Yilmaz, Meral] Cumhuriyet Univ, Fac Med, Dept Res Ctr, Sivas, Turkey -- [Tas, Ayca] Cumhuriyet Univ, Fac Hlth Sci, Dept Nutr & Diet, Sivas, Turkey -- [Kacan, Turgut] Cumhuriyet Univ, Fac Med, Dept Med Oncol, Sivas, Turkey -- [Sari, Musa] Cumhuriyet Univ, Fac Sci, Dept Biol, Sivas, Turkey -- [Silig, Yavuz] Cumhuriyet Univ, Fac Med, Dept Med Biochem, Sivas, Turkey |
| Jazyk: | angličtina |
| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
Oncology medicine.medical_specialty Turkish population Pathology business.industry Biochemistry (medical) Clinical Biochemistry medicine.disease Biochemistry 03 medical and health sciences 030104 developmental biology 0302 clinical medicine Murine double minute 2 (MDM2) gene 030220 oncology & carcinogenesis Internal medicine medicine Lung cancer Polymorphism business Molecular Biology |
| Popis: | WOS: 000405114700002 Introduction: Association between Murine double minute 2 T309G polymorphism and lung cancer risk has been investigated in several populations, but results of these studies are inconsistent. We aimed to investigate the effect of Murine double minute 2 T309G polymorphism on development of lung cancer in a Turkish population. Methods: Total 200 subjects including 100 patients and 100 controls were analyzed and used polymerase chain reaction and restriction fragment length polymorphism methods for genotyping analysis of the polymorphism. Results: We found that smokers compared with nonsmokers have approximately eight fold higher lung cancer risk [p = 0.0001, OR = 8.27 (4.02-16.9)]. Frequency of GG genotype was higher in patients than in controls, but this ratio was not significant (chi(2) = 3.5, p = 0.17). Genotype distribution of the polymorphism was not different neither patients with non-small cell lung cancer nor patients with small cell lung cancer (chi(2) = 2.89, p = 0.57). We analyzed together with demographic feature (except smoking habit), clinicopathological findings and genotype frequencies of this polymorphism, and any association with lung cancer risk was not obtained. Conclusion: No correlation between Murine double minute 2 T309G polymorphism and lung cancer risk was detected in this Turkish population. |
| Databáze: | OpenAIRE |
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