Effects of perineural invasion in prostate needle biopsy on tumor grade and biochemical recurrence rates after radical prostatectomy
| Autor: | Omer Demir, Serdar Çelik, Kutsal Yorukoglu, Ozan Bozkurt, Burçin Tuna, Güven Aslan, Ozgur Gurboga |
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| Rok vydání: | 2018 |
| Předmět: |
Male
Biochemical recurrence medicine.medical_specialty Biopsy medicine.medical_treatment 030232 urology & nephrology Perineural invasion Urology 03 medical and health sciences Tumor grade Prostate cancer Prostate needle biopsy 0302 clinical medicine Risk Factors Retropubic radical prostatectomy Humans Medicine Neoplasm Invasiveness Stage (cooking) Neoplasm Staging Retrospective Studies Prostatectomy lcsh:R5-920 business.industry Biopsy Needle Prostate Prostatic Neoplasms General Medicine Prostate-Specific Antigen medicine.disease 030220 oncology & carcinogenesis Neoplasm Grading lcsh:Medicine (General) business |
| Zdroj: | Kaohsiung Journal of Medical Sciences, Vol 34, Iss 7, Pp 385-390 (2018) |
| ISSN: | 2410-8650 1607-551X |
| Popis: | To predict local invasive disease before retropubic radical prostatectomy (RRP), the correlation of perineural invasion (PNI) on prostate needle biopsy (PNB) and RRP pathology data and the effect of PNI on biochemical recurrence (BR) were researched. For patients with RRP performed between 2005 and 2014, predictive and pathologic prognostic factors were assessed. Initially all and D'Amico intermediate-risk group patients were comparatively assessed in terms of being T2 or T3 stage on RRP pathology, positive or negative for PNI presence on PNB and positive or negative BR situation. Additionally the effect of PNI presence on recurrence-free survival (RFS) rate was investigated. When all patients are investigated, multivariate analysis observed that in T3 patients PSA, PNB Gleason score (GS) and tumor percentage were significantly higher; in PNI positive patients PNB GS, core number and tumor percentage were significantly higher and in BR positive patients PNB PNI positivity and core number were significantly higher compared to T2, PNI negative and BR negative patients, separately (p |
| Databáze: | OpenAIRE |
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