OBSTACLES IN THE APPLICATION OF MICROENCAPSULATION IN ISLET TRANSPLANTATION
| Autor: | Wm Fritschy, P Devos, Ghj Wolters, R Vanschilfgaarde |
|---|---|
| Přispěvatelé: | Man, Biomaterials and Microbes (MBM), Translational Immunology Groningen (TRIGR) |
| Jazyk: | angličtina |
| Rok vydání: | 1993 |
| Předmět: |
medicine.medical_specialty
Elevated blood glucose REVERSAL 030232 urology & nephrology Biomedical Engineering Medicine (miscellaneous) Bioengineering 030204 cardiovascular system & hematology ALGINATE-POLYLYSINE MICROCAPSULES GLUCOSE Biomaterials 03 medical and health sciences 0302 clinical medicine Internal medicine Insulin response medicine XENOGRAFTS MICROENCAPSULATION NOD mice geography INVITRO geography.geographical_feature_category ISLET TRANSPLANTATION business.industry Pancreatic islets Capsule DROPLET GENERATOR General Medicine Limiting PANCREATIC-ISLETS Islet NOD MICE Transplantation Endocrinology medicine.anatomical_structure ALGINATE RAT ISLETS CELLS business |
| Zdroj: | International journal of artificial organs, 16(4), 205-212. Wichtig Editore s.r.l. University of Groningen |
| ISSN: | 0391-3988 |
| Popis: | Several factors stand in the way of successful clinical transplantation of alginate-polylysine-alginate microencapsulated pancreatic islets. These obstacles can be classified into three categories. The first regards the technical aspects of the production process. Limiting factors are the insufficient ability to produce small capsules with an adequate production rate, and insufficient insight into the factors determining the optimal chemical and mechanical properties of the capsules. The second category regards the functional aspects of the microencapsulated islets, such as the limitations of the transplantation site and the absence of a physiologic insulin response of the encapsulated islets to elevated blood glucose levels. The third category regards the fact that survival times of encapsulated islet grafts are still limited to several weeks or months, which is mainly explained by a pericapsular fibrotic overgrowth reaction as a consequence of the bioincom-patibility of the capsule membrane. This study describes these obstacles, and thereby summarizes the requirements needed for successful clinical application of encapsulated islet transplantation. |
| Databáze: | OpenAIRE |
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