Pharmacokinetics of fluoxetine in horses following oral administration
| Autor: | Laura H. Waitt Wolker, Krista Pearman, Maria Lozoya, Jeffrey Norris, Charles A. Veltri |
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| Rok vydání: | 2021 |
| Předmět: |
Pharmacology
Fluoxetine Chromatography General Veterinary Resolution (mass spectrometry) Chemistry Administration Oral Horse Mass Spectrometry Single oral dose Bioactive metabolite Pharmacokinetics Liquid chromatography–mass spectrometry Oral administration medicine Animals Horses Chromatography Liquid Half-Life medicine.drug |
| Zdroj: | Journal of Veterinary Pharmacology and Therapeutics. 45:63-68 |
| ISSN: | 1365-2885 0140-7783 |
| DOI: | 10.1111/jvp.13029 |
| Popis: | This study aimed to investigate pharmacokinetics of fluoxetine in horses and validate a method for liquid chromatography mass spectrometry analysis of serum levels. Fluoxetine pharmacokinetics were determined using 10 healthy, adult horses. Fluoxetine pharmacokinetics following a single oral dose (0.25 mg/kg) were determined using blood samples collected prior to and at several time points over 7 days following administration. Serum concentrations of fluoxetine and its bioactive metabolite norfluoxetine were measured using liquid chromatography coupled to an accurate mass/high-resolution mass spectrometer. Pharmacokinetic parameters were estimated using a noncompartmental model. Time to maximum serum concentration and serum half-life of fluoxetine was 1.5 and 15.6 h, respectively. Steady-state serum concentrations were evaluated using five horses each receiving fluoxetine (0.25 mg/kg, PO, q24hrs) for 8 weeks and were found to be 62.9 ± 25.5 ng/ml on average. Norfluoxetine was not detected in any sample. |
| Databáze: | OpenAIRE |
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