High concentrations of activin A in the peritoneal fluid of women with epithelial ovarian cancer
| Autor: | Fernando M. Reis, Giovanni Scambia, Luigi Pirtoli, S. Danero, Stefano Luisi, Luigi Cobellis, Felice Petraglia |
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| Přispěvatelé: | Cobellis, Luigi, Reis, Fm, Luisi, S, Danero, S, Pirtoli, L, Scambia, G, Petraglia, F. |
| Jazyk: | angličtina |
| Rok vydání: | 2004 |
| Předmět: |
Adult
endocrine system medicine.medical_specialty endocrine system diseases Cystadenocarcinoma Endometriosis Reproductive medicine ovarian cyst Activin 03 medical and health sciences 0302 clinical medicine medicine Ascitic Fluid Humans Epithelial ovarian cancer ovarian cancer peritoneal fluid Aged Inhibin-beta Subunits Aged 80 and over Ovarian Neoplasms Gynecology 030219 obstetrics & reproductive medicine Ovarian cyst business.industry Peritoneal fluid Cystadenoma Serous Obstetrics and Gynecology Middle Aged medicine.disease female genital diseases and pregnancy complications Activins Survival Rate Activin a Serous fluid Embryology embryonic structures Cancer research Female Ovarian cancer business hormones hormone substitutes and hormone antagonists 030217 neurology & neurosurgery |
| Popis: | The aim of the present study was to evaluate the concentrations of activin A in the peritoneal fluid of women with epithelial (serous) ovarian cancer.A group of 160 women was studied and divided in four subgroups as follows: 1) serous ovarian carcinoma (n = 32); 2) serous ovarian cystadenoma (n = 20); 3) endometriosis (n = 53); and 4) healthy controls (n = 55), including both fertile (n = 32) and postmenopausal women (n = 23). Specimens of peritoneal fluid were collected during surgical interventions, and activin A was quantified using a specific two-site enzyme immunoassay.Peritoneal fluid activin A concentrations in women with ovarian carcinoma were about five-fold higher than those found in the control group (median [interquartile range] = 7.60 [2.85-10.15] and 1.50 [1.00-2.50] ng/mL, respectively, P.001). In contrast, the women with benign serous cystadenoma had peritoneal fluid activin A concentrations (1.50 [1.0-2.70] ng/mL) similar to those of the control group. High peritoneal fluid activin A levels (2 multiples of the mean) distinguished carcinoma from cystadenoma with a sensitivity of 72% and a specificity of 80%. The follow-up of nine patients with stage IIIc ovarian cancer showed no apparent relationship between the peritoneal fluid activin A levels and overall survival. No significant difference in peritoneal fluid activin A concentrations between patients with endometriosis and control women was observed.Most women with serous ovarian carcinoma had high concentrations of activin A in the peritoneal fluid, supporting a possible role of this growth factor in ovarian cancer. |
| Databáze: | OpenAIRE |
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