An imbalance in the production of IL-1 beta and IL-6 by monocytes of bipolar patients: restoration by lithium treatment

Autor: Willem A. Nolen, Ralph Kupka, Grard W. Akkerhuis, Harm de Wit, Esther M. Knijff, Cindy Ruwhof, Hemmo A. Drexhage, M. Nadine Breunis
Přispěvatelé: Interdisciplinary Centre Psychopathology and Emotion regulation (ICPE), Immunology, Child and Adolescent Psychiatry / Psychology, Human genetics
Jazyk: angličtina
Rok vydání: 2007
Předmět:
Lipopolysaccharides
Male
Lipopolysaccharide
Lithium (medication)
Interleukin-1beta
chemistry.chemical_compound
Ambulatory Care
IL-1 beta
Cells
Cultured
TUMOR-NECROSIS-FACTOR
bipolar disorder
biology
Interleukin
Middle Aged
TNF-ALPHA
Diagnostic and Statistical Manual of Mental Disorders
Psychiatry and Mental health
lithium
Lithium Compounds
Female
monocytes
medicine.drug
Adult
medicine.medical_specialty
SOLUBLE INTERLEUKIN-2 RECEPTOR
Enzyme-Linked Immunosorbent Assay
In Vitro Techniques
Proinflammatory cytokine
CEREBROSPINAL-FLUID
Internal medicine
medicine
Humans
BREAST-CANCER
Beta (finance)
Interleukin 6
PLASMA-LEVELS
Biological Psychiatry
Psychiatric Status Rating Scales
Psychotropic Drugs
IL-6
business.industry
Interleukin-6
MAJOR DEPRESSION
CYTOKINE PRODUCTION
IMMUNE ACTIVATION
ACUTE STATE
Endocrinology
chemistry
biology.protein
Lithium chloride
business
Lithium Chloride
Ex vivo
Zdroj: Bipolar Disorders, 9(7), 743-753. Wiley
Bipolar Disorders, 9(7), 743-753. Blackwell Publishing
Knijff, E M, Nadine, B M, Kupka, R W, De Wit, H J, Ruwhof, C, Akkerhuis, G W, Nolen, W A & Drexhage, H A 2007, ' An imbalance in the production of IL-1β and IL-6 by monocytes of bipolar patients : Restoration by lithium treatment ', Bipolar Disorders, vol. 9, no. 7, pp. 743-753 . https://doi.org/10.1111/j.1399-5618.2007.00444.x
Bipolar Disorders, 9(7), 743-753. Blackwell Munksgaard
ISSN: 1398-5647
DOI: 10.1111/j.1399-5618.2007.00444.x
Popis: Objectives: To study the ex vivo interleukin (IL)-1 beta and IL-6 production of monocytes in bipolar disorder (BD) patients in the absence/presence of lithium. Methods: Monocytes of outpatients with DSM-IV BD (n = 80, of whom 64 were lithium-treated) and of healthy control subjects (n = 59) were cultured in vitro and exposed (24 h) or not exposed to lipopolysaccharide (LPS) and/or graded concentrations of lithium chloride (LiCl). IL-1 beta and IL-6 production was assessed by enzyme-linked immunosorbent assay (ELISA) (supernatants). Results: Monocytes stimulated by LPS from non-lithium-treated bipolar patients were characterized by an abnormal IL-1 beta/IL-6 production ratio, i.e., low IL-1 beta and high IL-6 production. Lithium treatment increased IL-1 beta and decreased IL-6 production and thus restored the aberrant ratio. In vitro exposure of monocytes to LiCl did not have the same effects as lithium treatment: the procedure decreased IL-1 beta production and had minimal effects on IL-6 production. Conclusions: Blood monocytes have an altered proinflammatory status in BD. Lithium treatment restores this altered status. Short-term in vitro exposure of monocytes to lithium has other effects than lithium treatment.
Databáze: OpenAIRE
Externí odkaz: